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Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.

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Title: Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
Authors: Chang YH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Biomedical Translation Research Center, Academia Sinica, Taipei 115, Taiwan., Lee YC; Department of Nutrition Therapy, E-Da Cancer Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Dachang Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan., Chen SH; School of Nursing, Fooyin University, Kaohsiung 831, Taiwan., Fang SY; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Cheng TP; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Chi CH; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan., Tsai KC; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan., Chen PJ; Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: ed113510@edah.org.tw., Hung HY; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: z10308005@email.ncku.edu.tw.
Source: Biochemical pharmacology [Biochem Pharmacol] 2025 May; Vol. 235, pp. 116806. Date of Electronic Publication: 2025 Feb 14.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of a novel C2-functionalized chromen-4-one scaffold for the development of p38α MAPK signaling inhibitors to mitigate neutrophilic inflammatory responses.
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  Data: <searchLink fieldCode="AU" term="%22Chang+YH%22">Chang YH</searchLink>; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Biomedical Translation Research Center, Academia Sinica, Taipei 115, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YC%22">Lee YC</searchLink>; Department of Nutrition Therapy, E-Da Cancer Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition Therapy, E-Da Dachang Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Nutrition, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+SH%22">Chen SH</searchLink>; School of Nursing, Fooyin University, Kaohsiung 831, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fang+SY%22">Fang SY</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+TP%22">Cheng TP</searchLink>; Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chi+CH%22">Chi CH</searchLink>; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+KC%22">Tsai KC</searchLink>; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PJ%22">Chen PJ</searchLink>; Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: ed113510@edah.org.tw.<br /><searchLink fieldCode="AU" term="%22Hung+HY%22">Hung HY</searchLink>; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: z10308005@email.ncku.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%220101032%22">Biochemical pharmacology</searchLink> [Biochem Pharmacol] 2025 May; Vol. 235, pp. 116806. <i>Date of Electronic Publication: </i>2025 Feb 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0101032 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2968 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062952%22">00062952 </searchLink><i>NLM ISO Abbreviation: </i>Biochem Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bcp.2025.116806
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        Text: English
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              Text: 2025 May
              Type: published
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