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Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

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Title: Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.
Authors: Estevam GO; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States., Linossi E; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States., Rao J; Department of Computer Science, University of California, Los Angeles, Los Angeles, United States., Macdonald CB; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Ravikumar A; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Chrispens KM; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Biophysics Graduate Program, San Francisco, United States., Capra JA; Bakar Computational Health Sciences Institute and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States., Coyote-Maestas W; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States., Pimentel H; Department of Computer Science, University of California, Los Angeles, Los Angeles, United States.; Department of Computational Medicine and Human Genetics, University of California, Los Angeles, Los Angeles, United States.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States., Collisson EA; Human Biology, Fred Hutchinson Cancer Center, Seattle, United States.; Department of Medicine, University of Washington, Seattle, United States., Jura N; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States.
Source: ELife [Elife] 2025 Feb 17; Vol. 13. Date of Electronic Publication: 2025 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Estevam+GO%22">Estevam GO</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Tetrad Graduate Program, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Linossi+E%22">Linossi E</searchLink>; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Rao+J%22">Rao J</searchLink>; Department of Computer Science, University of California, Los Angeles, Los Angeles, United States.<br /><searchLink fieldCode="AU" term="%22Macdonald+CB%22">Macdonald CB</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ravikumar+A%22">Ravikumar A</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Chrispens+KM%22">Chrispens KM</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Biophysics Graduate Program, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Capra+JA%22">Capra JA</searchLink>; Bakar Computational Health Sciences Institute and Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Coyote-Maestas+W%22">Coyote-Maestas W</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Pimentel+H%22">Pimentel H</searchLink>; Department of Computer Science, University of California, Los Angeles, Los Angeles, United States.; Department of Computational Medicine and Human Genetics, University of California, Los Angeles, Los Angeles, United States.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.<br /><searchLink fieldCode="AU" term="%22Collisson+EA%22">Collisson EA</searchLink>; Human Biology, Fred Hutchinson Cancer Center, Seattle, United States.; Department of Medicine, University of Washington, Seattle, United States.<br /><searchLink fieldCode="AU" term="%22Jura+N%22">Jura N</searchLink>; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, United States.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Fraser+JS%22">Fraser JS</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, United States.
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