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Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

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Title: Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.
Authors: Choudhury A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Kulkarni AV; Asian Institute of Gastroenterology Hospitals, Hyderabad, India., Arora V; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Soin AS; Medanta-The Medicity Hospital, Gurugram, Haryana, India., Dokmeci AK; Ankara University School of Medicine, Ankara, Turkey., Chowdhury A; Institute of Post-Graduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India., Koshy A; VPS Lakeshore Hospital and Research Center Ltd, Kochi, Kerala, India., Duseja A; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Kumar A; Govind Ballabh Pant Hospital, New Delhi, India., Mishra AK; Sanjay Gandhi Post Graduate Institute (SGPGI), Lucknow, Uttar Pradesh, India., Patwa AK; King George's Medical University, Lucknow, India., Sood A; Dayanand Medical College, Ludhiana, India., Roy A; Apollo Multispeciality Hospital, Kolkata, India., Shukla A; Seth G S Medical College and K E M Hospital, Mumbai, Maharashtra, India.; Sir HN Reliance Foundation Hospital, Girgaon, Mumbai, Maharashtra, India., Chan A; Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Krag A; University of Southern Denmark, Odense, Denmark., Mukund A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Mandot A; Global Hospital, Mumbai, India., Goel A; Sanjay Gandhi Post Graduate Institute (SGPGI), Lucknow, Uttar Pradesh, India., Butt AS; Aga Khan University Hospital, Karachi, Pakistan., Sahney A; BLK-Max Super Specialty Hospital, New Delhi, India., Shrestha A; Alka Hospital, Kathmandu, Nepal., Cárdenas A; Univerity of Barcelona Institut d'Investigacions Biomèdiques August Pi-Sunyer, Barcelona, Spain., Di Giorgio A; Hospital Papa Giovanni XXIII, Bergamo, Italy., Arora A; Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India., Anand AC; Kalinga Institute of Medical Sciences (KIMS), Bhubaneshwar, Orissa, India., Dhawan A; King's College Hospital, London, UK., Jindal A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Saraya A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Srivastava A; Sanjay Gandhi Post Graduate Institute (SGPGI), Lucknow, Uttar Pradesh, India., Kumar A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Kaewdech A; Prince-of Song-Kla University, Songkhla, Thailand., Pande A; Fortis Hospital, Greater Noida, Uttar Pradesh, India., Rastogi A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Valsan A; Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India., Goel A; Christian Medical College (CMC), Vellore, India., Kumar A; Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India., Singal AK; University of Louisville School of Medicine, Trager Transplant Center and Jewish Hospital, Louisville, KY, USA., Tanaka A; Teikyo University School of Medicine, Tokyo, Japan., Coilly A; Centre Hepato-Biliaire, Paul Brousse Hospital, Paris-Saclay University, Villejuif, France., Singh A; IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India., Meena BL; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Jagadisan B; King's College Hospital, London, UK., Sharma BC; Govind Ballabh Pant Hospital, New Delhi, India., Lal BB; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Eapen CE; Christian Medical College (CMC), Vellore, India., Yaghi C; Saint Joseph University, Hôtel-Dieu de France University Medical Center, Beirut, Lebanon., Kedarisetty CK; Gleneagles Global Hospitals, Hyderabad, Telangana, India., Kim CW; The Catholic University of Korea, Seoul, Korea., Panackel C; Aster Medicity, Ernakulam, Kerala, India., Yu C; Capital Medical University, Beijing, China., Kalal CR; Nanavati Max Super Specialty Hospital, Mumbai, Maharashtra, India., Bihari C; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Huang CH; Linkou Chang-Gung Memorial Hospital, Taoyuan, Taiwan., Vasishtha C; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Jansen C; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Strassburg C; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Lin CY; Linkou Medical Centre, Chang Gung Memorial Hospital, Keelung, Taiwan., Karvellas CJ; University of Alberta, Edmonton, AB, Canada., Lesmana CRA; Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia.; Medistra Hospital, Jakarta, Indonesia., Philips CA; The Liver Institute, Rajagari Hospital, Aluva, Kerala, India., Shawcross D; King's College Hospital, London, UK., Kapoor D; Gleneagles Global Hospitals, Hyderabad, Telangana, India., Agrawal D; PACE Hospital, Hyderabad, India., Payawal DA; Fatima Medical University Hospital, Valenzuela Metro Manila, Philippines., Praharaj DL; Kalinga Institute of Medical Sciences (KIMS), Bhubaneshwar, Orissa, India., Jothimani D; Dr. Rela Institute and Medical Centre, Chennai, India., Song DS; The Catholic University of Korea, Seoul, Korea., Kim DJ; Hallym University, Chuncheon, Republic of Korea., Kim DS; Korea University College of Medicine, Seoul, Republic of Korea., Zhongping D; Capital Medical University, Beijing, China., Karim F; Sir Salimullah Medical College, Mitford Hospital, Dhaka, Bangladesh., Durand F; Université de Paris, AP-HP, C, DMU DIGEST, Centre de Référence Des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Centre de Recherche Sur L'inflammation, Inserm, Paris, France., Shiha GE; Mansoura University, Mansoura, Egypt., D'Amico G; Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.; Clinica La Maddalena, Palermo, Italy., Lau GK; Humanity and Health Medical Center, Hongkong, SAR, China., Pati GK; IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India., Narro GEC; Hospital Médica Sur, Mexico City, Mexico.; Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubiran',, Mexico City, Mexico.; Latin-American Association for the Study of the Liver (ALEH), Santiago de Chile, Chile., Lee GH; National University Hospital, National University of Singapore, Singapore, Singapore., Adali G; University of Health Sciences, Ümraniye, Istanbul, Turkey., Dhakal GP; Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan., Szabo G; Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Lin HC; Taipei Veterans General Hospital, Taipei, Taiwan., Li H; School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China., Nair HK; Ernakulam Medical Center (EMC), Kinder Multispeciality Hospital, Kochi, Kerala, India., Devarbhavi H; St. John's Medical College and Hospital, Bangalore, India., Tevethia H; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Ghazinian H; Yerevan Medical Scientific Center, Yerevan, Armenia., Ilango H; MIOT International Hospital, Chennai, India., Yu HL; Capital Medical University, Beijing, China., Hasan I; Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia., Fernandez J; University of Barcelona, IDIBAPS and CIBEREHD, Barcelona, Spain., George J; Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia., Behari J; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Fung J; Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Bajaj J; Virginia Commonwealth University, Richmond, VA, USA., Benjamin J; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Lai JC; University of California, San Francisco, San Francisco, CA, USA., Jia J; Capital Medical University, Beijing, China., Hu JH; The Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China., Chen JJ; Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Hou JL; Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China., Yang JM; The Catholic University of Korea, Seoul, Korea., Chang J; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Trebicka J; Medizinische Klinik B, Universitätsklinikum Münster, Münster, Germany., Kalf JC; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Sollano JD; Department of Medicine, Cardinal Santos Medical Center, Manila, Philippines., Varghese J; Gleneagles Global Hospital, Chennai, Tamil Nadu, India., Arab JP; Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.; Schulich School of Medicine, Western University, London, ON, Canada., Li J; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China., Reddy KR; University of Pennsylvania, Philadelphia, PA, USA., Raja K; King's College Hospital London, Dubai, United Arab Emirates., Panda K; IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India., Kajal K; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Kumar K; Mahatma Gandhi Medical College, Jaipur, Rajasthan, India., Madan K; Max Super Specialty Hospital Saket, New Delhi, India., Kalista KF; Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia., Thanapirom K; Chulalongkorn University, Bangkok, Thailand., Win KM; University of Medicine, Yangon Ministry of Health, Yangon, Myanmar., Suk KT; Hallym University, Chuncheon, Republic of Korea., Devadas K; Government Medical College, Thiruvananthapuram, Kerala, India., Lesmana LA; Medistra Hospital, Jakarta, Indonesia., Kamani L; Liaquat National Hospital, Karachi, Sindh, Pakistan., Premkumar M; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Niriella MA; University of Kelaniya, Ragama, Sri Lanka., Al Mahtab M; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Yuen MF; Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Sayed MH; Ain Shams University, Cairo, Egypt., Alla M; Asian Institute of Gastroenterology Hospitals, Hyderabad, India., Wadhawan M; BLK-Max Super Specialty Hospital, New Delhi, India., Sharma MK; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Sahu M; IMS and SUM Hospital, SOA University, Bhubaneswar, Odisha, India., Prasad M; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Muthiah MD; National University Hospital, National University of Singapore, Singapore, Singapore., Schulz M; Goethe University Clinic Frankfurt, Frankfurt, Germany., Bajpai M; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Reddy MS; Department of Medicine, Cardinal Santos Medical Center, Manila, Philippines., Praktiknjo M; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Yu ML; Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.; College of Medicine, National Sun Yet-Sen University, Kaohsiung, Taiwan., Prasad M; VGM Gastro Hospital, Coimbatore, India., Sharma M; Asian Institute of Gastroenterology Hospitals, Hyderabad, India., Elbasiony M; Mansoura University, Mansoura, Egypt., Eslam M; Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia., Azam MG; Endocrine and Metabolic Disorder (BIRDEM) Shahbad, Bangladesh Institute of Research and Rehabilitation in Diabetes, Dhaka, Bangladesh., Rela M; Dr. Rela Institute and Medical Centre, Chennai, India., Desai MS; Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA., Vij M; Dr. Rela Institute and Medical Centre, Chennai, India., Mahmud N; University of Pennsylvania, Philadelphia, PA, USA., Choudhary NS; Medanta-The Medicity Hospital, Gurugram, Haryana, India., Marannan NK; Dr. Rela Institute and Medical Centre, Chennai, India., Ormeci N; İstanbul Health and Technology University, Istanbul, Turkey., Saraf N; Medanta-The Medicity Hospital, Gurugram, Haryana, India., Verma N; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Nakayama N; Saitama Medical University, Iruma-Gun, Japan., Kawada N; Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Oidov Baatarkhuu; Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Goyal O; Dayanand Medical College, Ludhiana, India., Yokosuka O; Graduate School of Medicine, Chiba University, Chuo-Ku, Chiba, Japan., Rao PN; Asian Institute of Gastroenterology Hospitals, Hyderabad, India., Angeli P; Department of Medicine (DIMED), University of Padova, Padua, Italy., Parikh P; Zydus Hospital, Ahmedabad, Gujarat, India., Kamath PS; Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Thuluvath PJ; Mercy Medical Center, Baltimore, USA., Lingohr P; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Ranjan P; All India Institute of Medical Sciences (AIIMS), New Delhi, India., Bhangui P; Medanta-The Medicity Hospital, Gurugram, Haryana, India., Rathi P; Topi Wala National (TN) Medical College and BYL Nair Charitable Hospital, Mumbai, India., Sakhuja P; Govind Ballabh Pant Hospital, New Delhi, India., Puri P; Virginia Commonwealth University, Richmond, VA, USA., Ning Q; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Dhiman RK; Sanjay Gandhi Post Graduate Institute (SGPGI), Lucknow, Uttar Pradesh, India., Kumar R; Changi General Hospital, Singapore, Singapore., Vijayaraghavan R; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Khanna R; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Maiwall R; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Mohanka R; Sir HN Reliance Foundation Hospital, Girgaon, Mumbai, Maharashtra, India., Moreau R; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.; Centre de Recherche Sur L'Inflammation (CRI), INSERM and Université Paris-Cité, Paris, France.; Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Beaujon, Service d'Hépatologie, Clichy, France., Gani RA; Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia., Loomba R; University of California, San Diego, La Jolla, CA, USA., Mehtani R; Amrita Institute of Medical Sciences and Research Centre, Faridabad, Haryana, India., Rajaram RB; University of Malaya, Kuala Lumpur, Malaysia., Hamid SS; Aga Khan University Hospital, Karachi, Pakistan., Palnitkar S; Deenanath Mangeshkar Hospital and Research Centre, Pune, India., Lal S; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Biswas S; All India Institute of Medical Sciences (AIIMS), New Delhi, India., Chirapongsathorn S; Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand., Agarwal S; All India Institute of Medical Sciences (AIIMS), New Delhi, India., Sachdeva S; Govind Ballabh Pant Hospital, New Delhi, India., Saigal S; Max Super Specialty Hospital Saket, New Delhi, India., Kumar SE; Christian Medical College (CMC), Vellore, India., Violeta S; Violeta Medical Centre, Yerevan, Armenia., Singh SP; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Mochida S; Saitama Medical University, Iruma-Gun, Japan., Mukewar S; Midas Multispeciality Hospital Pvt. Ltd, Nagpur, Maharashtra, India., Alam S; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Lim SG; National University Hospital, National University of Singapore, Singapore, Singapore., Alam S; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Shalimar; All India Institute of Medical Sciences (AIIMS), New Delhi, India., Venishetty S; Asian Institute of Gastroenterology Hospitals, Hyderabad, India., Sundaram SS; Digestive Health Institute, Children's Hospital, Aurora, CO, USA., Shetty S; Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Bhatia S; National Institute of Medical Sciences, Jaipur, India., Singh SA; Max Super Specialty Hospital Saket, New Delhi, India., Kottilil S; University of Maryland School of Medicine, Baltimore, USA., Strasser S; Royal Prince Alfred Hospital, Sydney, Australia., Shasthry SM; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Maung ST; Chulalongkorn University, Bangkok, Thailand., Tan SS; Selayang Hospital, University of Malaysia, Batu Caves, Selangor, Malaysia., Treeprasertsuk S; Chulalongkorn University, Bangkok, Thailand., Asthana S; Aster CMI Hospital, Bengaluru, Karnataka, India., Manekeller S; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Gupta S; Max Super Specialty Hospital Saket, New Delhi, India., Acharya SK; KIIT University, Fortis Escorts Hospital, Okhla, New Delhi, India., K C S; Bir Hospital, National Academy of Medical Sciences, Kathmandu, Nepal., Maharshi S; Sawai Man Singh (SMS) Medical College and Hospital, Jaipur, Rajasthan, India., Asrani S; Baylor Simmons Transplant Institute, Dallas, TX, USA., Dadhich S; Dr Sampuranand Medical College (SNMC), Jodhpur, Rajasthan, India., Taneja S; Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Giri S; Kalinga Institute of Medical Sciences (KIMS), Bhubaneshwar, Orissa, India., Singh S; Sanjay Gandhi Post Graduate Institute (SGPGI), Lucknow, Uttar Pradesh, India., Chen T; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Gupta T; Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India., Kanda T; Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan., Tanwandee T; Siriraj Hospital, Mahidol University, Bangkok, Thailand., Piratvishuth T; Prince-of Song-Kla University, Songkhla, Thailand., Spengler U; Department of Internal Medicine I, University of Bonn, Bonn, Germany., Prasad VGM; Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA., Midha V; Dayanand Medical College, Ludhiana, India., Rakhmetova V; Astana Medical University, Astana, Kazakhstan., Arroyo V; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain., Sood V; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Br VK; Mazumdar Shaw Medical Centre, Bangalore, Karnataka, India., Wong VW; Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Pamecha V; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Singh V; Punjab Institute of Liver and Biliary Sciences, Mohali, Punjab, India., Dayal VM; Indira Gandhi Institute of Medical Sciences, (IGIMS), Bely Road Patna, Bihar, India., Saraswat VA; Mahatma Gandhi Medical College, Jaipur, Rajasthan, India., Kim W; Stanford University, Stanford, CA, USA., Jafri W; Aga Khan University Hospital, Karachi, Pakistan., Gu W; Goethe University Clinic Frankfurt, Frankfurt, Germany., Jun WY; Changi General Hospital, Singapore, Singapore., Qi X; Medical School, Zhongda Hospital, Southeast University, Nanjing, China., Chawla YK; Kalinga Institute of Medical Sciences (KIMS), Bhubaneshwar, Orissa, India., Kim YJ; Seoul National University College of Medicine, Seoul, Republic of Korea., Shi Y; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China., Abbas Z; Ziauddin University Hospital Karachi, Karachi, Pakistan., Kumar G; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India., Shiina S; Juntendo University, Tokyo, Japan., Wei L; Changgung Hospital, Tsinghua University, Beijing, China., Omata M; Yamanashi Central Hospital, Yamanashi, Japan., Sarin SK; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India. shivsarin@gmail.com.
Corporate Authors: APASL-ACLF Research Consortium (AARC) for APASL-ACLF working party
Source: Hepatology international [Hepatol Int] 2025 Feb; Vol. 19 (1), pp. 1-69. Date of Electronic Publication: 2025 Feb 17.
Publication Type: Journal Article; Review; Consensus Statement
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101304009 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-0541 (Electronic) Linking ISSN: 19360533 NLM ISO Abbreviation: Hepatol Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1936-0541
DOI:10.1007/s12072-024-10773-4