Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.

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Title: Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.
Authors: Zheng SL; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Jurgens SJ; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McGurk KA; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Xu X; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Grace C; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Theotokis PI; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Buchan RJ; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Francis C; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., de Marvao A; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Women and Children's Health, King's College London, London, UK.; School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK., Curran L; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Bai W; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Pua CJ; National Heart Research Institute Singapore, National Heart Center, Singapore, Singapore., Tang HC; Department of Cardiology, National Heart Centre, Singapore, Singapore., Jorda P; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., van Slegtenhorst MA; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Verhagen JMA; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Harper AR; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ormondroyd E; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Chin CWL; Department of Cardiology, National Heart Centre, Singapore, Singapore., Pantazis A; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Baksi J; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Halliday BP; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Matthews P; Department of Brain Sciences, Imperial College London, London, UK., Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Walsh R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Amin AS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Wilde AAM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Cook SA; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Cardiology, National Heart Centre, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore., Prasad SK; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Barton PJR; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., O'Regan DP; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Lumbers RT; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Goel A; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Tadros R; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Michels M; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Watkins H; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Ware JS; National Heart Lung Institute, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK. j.ware@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, UK. j.ware@imperial.ac.uk.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. j.ware@imperial.ac.uk.
Corporate Authors: HCM GWAS Collaborators
Source: Nature genetics [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 563-571. Date of Electronic Publication: 2025 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-025-02094-5