Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings.
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| Title: | Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings. |
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| Authors: | Zheng SL; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Jurgens SJ; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McGurk KA; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Xu X; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Grace C; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Theotokis PI; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Buchan RJ; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Francis C; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., de Marvao A; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Women and Children's Health, King's College London, London, UK.; School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK., Curran L; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Bai W; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Pua CJ; National Heart Research Institute Singapore, National Heart Center, Singapore, Singapore., Tang HC; Department of Cardiology, National Heart Centre, Singapore, Singapore., Jorda P; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., van Slegtenhorst MA; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Verhagen JMA; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Harper AR; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ormondroyd E; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Chin CWL; Department of Cardiology, National Heart Centre, Singapore, Singapore., Pantazis A; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Baksi J; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Halliday BP; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Matthews P; Department of Brain Sciences, Imperial College London, London, UK., Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Walsh R; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Amin AS; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Wilde AAM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Cook SA; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Cardiology, National Heart Centre, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore., Prasad SK; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., Barton PJR; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK., O'Regan DP; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK., Lumbers RT; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Goel A; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Tadros R; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., Michels M; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands., Watkins H; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Bezzina CR; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France., Ware JS; National Heart Lung Institute, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK. j.ware@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, UK. j.ware@imperial.ac.uk.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. j.ware@imperial.ac.uk. |
| Corporate Authors: | HCM GWAS Collaborators |
| Source: | Nature genetics [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 563-571. Date of Electronic Publication: 2025 Feb 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39966645 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Evaluation of polygenic scores for hypertrophic cardiomyopathy in the general population and across clinical settings. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Zheng+SL%22">Zheng SL</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Jurgens+SJ%22">Jurgens SJ</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22McGurk+KA%22">McGurk KA</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Grace+C%22">Grace C</searchLink>; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Theotokis+PI%22">Theotokis PI</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Buchan+RJ%22">Buchan RJ</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Francis+C%22">Francis C</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22de+Marvao+A%22">de Marvao A</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Women and Children's Health, King's College London, London, UK.; School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Curran+L%22">Curran L</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Bai+W%22">Bai W</searchLink>; Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pua+CJ%22">Pua CJ</searchLink>; National Heart Research Institute Singapore, National Heart Center, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tang+HC%22">Tang HC</searchLink>; Department of Cardiology, National Heart Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Jorda+P%22">Jorda P</searchLink>; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22van+Slegtenhorst+MA%22">van Slegtenhorst MA</searchLink>; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhagen+JMA%22">Verhagen JMA</searchLink>; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Harper+AR%22">Harper AR</searchLink>; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ormondroyd+E%22">Ormondroyd E</searchLink>; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chin+CWL%22">Chin CWL</searchLink>; Department of Cardiology, National Heart Centre, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pantazis+A%22">Pantazis A</searchLink>; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Baksi+J%22">Baksi J</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Halliday+BP%22">Halliday BP</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+P%22">Matthews P</searchLink>; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pinto+YM%22">Pinto YM</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.<br /><searchLink fieldCode="AU" term="%22Walsh+R%22">Walsh R</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Amin+AS%22">Amin AS</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.<br /><searchLink fieldCode="AU" term="%22Wilde+AAM%22">Wilde AAM</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; Department of Clinical Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.<br /><searchLink fieldCode="AU" term="%22Cook+SA%22">Cook SA</searchLink>; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Department of Cardiology, National Heart Centre, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Prasad+SK%22">Prasad SK</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Barton+PJR%22">Barton PJR</searchLink>; National Heart Lung Institute, Imperial College London, London, UK.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Regan+DP%22">O'Regan DP</searchLink>; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lumbers+RT%22">Lumbers RT</searchLink>; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Goel+A%22">Goel A</searchLink>; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tadros+R%22">Tadros R</searchLink>; Cardiovascular Genetics Centre, Montreal Heart Institute, Montreal, Quebec, Canada.; Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Michels+M%22">Michels M</searchLink>; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.; Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Radcliffe Department of Medicine, University of Oxford, Division of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bezzina+CR%22">Bezzina CR</searchLink>; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ware+JS%22">Ware JS</searchLink>; National Heart Lung Institute, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Medical Research Council Laboratory of Medical Sciences, Imperial College London, London, UK. j.ware@imperial.ac.uk.; Royal Brompton & Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK. j.ware@imperial.ac.uk.; Imperial College Healthcare NHS Trust, London, UK. j.ware@imperial.ac.uk.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. j.ware@imperial.ac.uk. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22HCM+GWAS+Collaborators%22">HCM GWAS Collaborators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2025 Mar; Vol. 57 (3), pp. 563-571. <i>Date of Electronic Publication: </i>2025 Feb 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE |
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