The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.
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| Title: | The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers. |
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| Authors: | Goldstein O; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shani S; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Gana-Weisz M; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Elkoshi N; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Casey F; Formerly Biogen Inc, Cambridge, MA, USA., Sun YH; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA., Chandratre K; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA., Cedarbaum JM; Formerly Biogen Inc, Cambridge, MA, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Blauwendraat C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Bar-Shira A; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Thaler A; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Gurevich T; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Mirelman A; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Giladi N; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Brain Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Orr-Urtreger A; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Alcalay RN; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. |
| Source: | Journal of Parkinson's disease [J Parkinsons Dis] 2025 Mar; Vol. 15 (2), pp. 291-299. Date of Electronic Publication: 2025 Jan 17. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1877-718X |
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| DOI: | 10.1177/1877718X241310722 |
