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The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.

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Title: The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.
Authors: Goldstein O; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Shani S; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Gana-Weisz M; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Elkoshi N; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Casey F; Formerly Biogen Inc, Cambridge, MA, USA., Sun YH; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA., Chandratre K; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA., Cedarbaum JM; Formerly Biogen Inc, Cambridge, MA, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Blauwendraat C; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Bar-Shira A; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Thaler A; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Gurevich T; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Mirelman A; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Giladi N; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Brain Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Orr-Urtreger A; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel., Alcalay RN; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Source: Journal of Parkinson's disease [J Parkinsons Dis] 2025 Mar; Vol. 15 (2), pp. 291-299. Date of Electronic Publication: 2025 Jan 17.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101567362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.
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  Data: <searchLink fieldCode="AU" term="%22Goldstein+O%22">Goldstein O</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Shani+S%22">Shani S</searchLink>; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Gana-Weisz+M%22">Gana-Weisz M</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Elkoshi+N%22">Elkoshi N</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Casey+F%22">Casey F</searchLink>; Formerly Biogen Inc, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+YH%22">Sun YH</searchLink>; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chandratre+K%22">Chandratre K</searchLink>; Research Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cedarbaum+JM%22">Cedarbaum JM</searchLink>; Formerly Biogen Inc, Cambridge, MA, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Blauwendraat+C%22">Blauwendraat C</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Shira+A%22">Bar-Shira A</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Thaler+A%22">Thaler A</searchLink>; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Gurevich+T%22">Gurevich T</searchLink>; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Mirelman+A%22">Mirelman A</searchLink>; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Laboratory for Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Giladi+N%22">Giladi N</searchLink>; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Brain Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Orr-Urtreger+A%22">Orr-Urtreger A</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Alcalay+RN%22">Alcalay RN</searchLink>; Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.; Movement disorders Center, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%22101567362%22">Journal of Parkinson's disease</searchLink> [J Parkinsons Dis] 2025 Mar; Vol. 15 (2), pp. 291-299. <i>Date of Electronic Publication: </i>2025 Jan 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101567362 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1877-718X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218777171%22">18777171 </searchLink><i>NLM ISO Abbreviation: </i>J Parkinsons Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1177/1877718X241310722
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