Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance.

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Title: Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance.
Authors: Hoeferlin GF; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Grabinski SE; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Druschel LN; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Duncan JL; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Burkhart G; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Weagraff GR; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.; Department of Biology, University of Florida, Gainesville, FL, USA., Lee AH; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Hong C; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Bambroo M; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Olivares H; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Bajwa T; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Coleman J; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Li L; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Memberg W; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Sweet J; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.; Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, OH, USA., Hamedani HA; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.; Department of Materials Science and Engineering, Case Western Reserve University, Cleveland, OH, USA., Acharya AP; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA., Hernandez-Reynoso AG; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Department of Bioengineering, The University of Texas at Dallas, Richardson, TX, USA., Donskey C; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.; Division of Infectious Diseases & HIV Medicine in the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Jaskiw G; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA., Ricky Chan E; Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Shoffstall AJ; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Bolu Ajiboye A; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., von Recum HA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA., Zhang L; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. lxz716@case.edu.; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. lxz716@case.edu., Capadona JR; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. jrc35@case.edu.; Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA. jrc35@case.edu.
Source: Nature communications [Nat Commun] 2025 Feb 20; Vol. 16 (1), pp. 1829. Date of Electronic Publication: 2025 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-025-56979-4