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Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer.

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Title: Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer.
Authors: Roesel R; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Strati F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Basso C; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Epistolio S; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland., Spina P; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland., Djordjevic J; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Sorrenti E; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Villa M; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Cianfarani A; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Mongelli F; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Galafassi J; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Popeskou SG; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Facciotti F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Caprera C; Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy., Melle F; Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy., Majno-Hurst PE; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland., Franzetti-Pellanda A; Service of Radiotherapy, Gruppo Ospedaliero Moncucco, Clinica Moncucco, Lugano, Switzerland., De Dosso S; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Medical Oncology, Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Bonfiglio F; Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy.; CEINGE Advanced Biotechnology Franco Salvatore, Università degli Studi di Napoli Federico II, Naples, Italy., Frattini M; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland., Christoforidis D; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Visceral Surgery, CHUV, University of Lausanne, Lausanne, Switzerland., Iezzi G; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Source: Oncoimmunology [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2465015. Date of Electronic Publication: 2025 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE
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  Data: Combined tumor-associated microbiome and immune gene expression profiling predict response to neoadjuvant chemo-radiotherapy in locally advanced rectal cancer.
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  Data: <searchLink fieldCode="AU" term="%22Roesel+R%22">Roesel R</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Strati+F%22">Strati F</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Basso+C%22">Basso C</searchLink>; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Epistolio+S%22">Epistolio S</searchLink>; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Spina+P%22">Spina P</searchLink>; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Djordjevic+J%22">Djordjevic J</searchLink>; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sorrenti+E%22">Sorrenti E</searchLink>; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Villa+M%22">Villa M</searchLink>; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cianfarani+A%22">Cianfarani A</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mongelli+F%22">Mongelli F</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Galafassi+J%22">Galafassi J</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Popeskou+SG%22">Popeskou SG</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Facciotti+F%22">Facciotti F</searchLink>; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Caprera+C%22">Caprera C</searchLink>; Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Melle+F%22">Melle F</searchLink>; Division of Hematopathology, IEO European Institute of Oncology IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Majno-Hurst+PE%22">Majno-Hurst PE</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Franzetti-Pellanda+A%22">Franzetti-Pellanda A</searchLink>; Service of Radiotherapy, Gruppo Ospedaliero Moncucco, Clinica Moncucco, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22De+Dosso+S%22">De Dosso S</searchLink>; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Medical Oncology, Oncology Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonfiglio+F%22">Bonfiglio F</searchLink>; Department of Molecular Medicine and Medical Biotechnology, University of Naples, Naples, Italy.; CEINGE Advanced Biotechnology Franco Salvatore, Università degli Studi di Napoli Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Frattini+M%22">Frattini M</searchLink>; Laboratory of Molecular Pathology, Institute of Pathology, Locarno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Christoforidis+D%22">Christoforidis D</searchLink>; Department of Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.; Department of Visceral Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Iezzi+G%22">Iezzi G</searchLink>; Laboratory for Translational Surgical Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101570526%22">Oncoimmunology</searchLink> [Oncoimmunology] 2025 Dec; Vol. 14 (1), pp. 2465015. <i>Date of Electronic Publication: </i>2025 Feb 24.
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