Sublingual caffeine delivery via oral spray does not accelerate blood caffeine increase compared to ingestion of caffeinated beverages.

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Title: Sublingual caffeine delivery via oral spray does not accelerate blood caffeine increase compared to ingestion of caffeinated beverages.
Authors: McCarthy DG; Human Performance & Health Research Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.; Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Stapleton RK; Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Handy RM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Amanual S; Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Tsioros S; Human Performance & Health Research Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Millar PJ; Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada., Burr JF; Human Performance & Health Research Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada. burrj@uoguelph.ca.
Source: European journal of applied physiology [Eur J Appl Physiol] 2025 Jul; Vol. 125 (7), pp. 2007-2013. Date of Electronic Publication: 2025 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1439-6327
DOI:10.1007/s00421-025-05735-z