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Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.

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Title: Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.
Authors: Škapik IP; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany.; Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Frankfurt am Main, Germany., Giacomelli C; CRUK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK., Hahn S; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany.; Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Frankfurt am Main, Germany., Deinlein H; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Gallant P; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany., Diebold M; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074, Würzburg, Germany., Biayna J; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany.; Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590, Frankfurt am Main, Germany., Hendricks A; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Olimski L; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Otto C; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Kastner C; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Wolf E; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Institute of Biochemistry, CAU Kiel, 24118, Kiel, Germany., Schülein-Völk C; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany., Maurus K; Institute of Pathology, University of Würzburg, 97074, Würzburg, Germany., Rosenwald A; Institute of Pathology, University of Würzburg, 97074, Würzburg, Germany., Schleussner N; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, University Heidelberg, 69120, Heidelberg, Germany.; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), DKFZ, Core Center Heidelberg, Heidelberg, Germany., Jackstadt RF; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany.; Cancer Progression and Metastasis Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; German Cancer Consortium (DKTK), DKFZ, Core Center Heidelberg, Heidelberg, Germany., Schlegel N; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany., Germer CT; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, 97080, Würzburg, Germany., Bushell M; CRUK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK., Eilers M; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, 97080, Würzburg, Germany., Schmidt S; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany. schmidt_s12@ukw.de.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany. schmidt_s12@ukw.de., Wiegering A; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany. wiegering_a@ukw.de.; Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital Würzburg, 97080, Würzburg, Germany. wiegering_a@ukw.de.; Goethe University Frankfurt, University Hospital, Department of General, Visceral, Transplant and Thoracic Surgery, Frankfurt am Main, Germany. wiegering_a@ukw.de.; Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, 97080, Würzburg, Germany. wiegering_a@ukw.de.
Source: The EMBO journal [EMBO J] 2025 Apr; Vol. 44 (7), pp. 2075-2105. Date of Electronic Publication: 2025 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2075
DOI:10.1038/s44318-025-00381-9