High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

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Bibliographic Details
Title: High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.
Authors: Garcia AM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Davis AK; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Martinez-Ramos C; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Morishima Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Lau M; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Xu E; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Sunil A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Zhang H; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Alt A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan; Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan., Lieberman AP; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan., Osawa Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: osawa@umich.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2025 Feb; Vol. 107 (2), pp. 100008. Date of Electronic Publication: 2024 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-0111
DOI:10.1016/j.molpha.2024.100008