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High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

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Title: High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.
Authors: Garcia AM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Davis AK; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Martinez-Ramos C; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Morishima Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Lau M; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Xu E; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Sunil A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Zhang H; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan., Alt A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan; Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan., Lieberman AP; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan., Osawa Y; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: osawa@umich.edu.
Source: Molecular pharmacology [Mol Pharmacol] 2025 Feb; Vol. 107 (2), pp. 100008. Date of Electronic Publication: 2024 Dec 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.
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  Data: <searchLink fieldCode="AU" term="%22Garcia+AM%22">Garcia AM</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Davis+AK%22">Davis AK</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Martinez-Ramos+C%22">Martinez-Ramos C</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Morishima+Y%22">Morishima Y</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Lau+M%22">Lau M</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Xu+E%22">Xu E</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Sunil+A%22">Sunil A</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Alt+A%22">Alt A</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan; Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Lieberman+AP%22">Lieberman AP</searchLink>; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Osawa+Y%22">Osawa Y</searchLink>; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: osawa@umich.edu.
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  Data: <searchLink fieldCode="JN" term="%220035623%22">Molecular pharmacology</searchLink> [Mol Pharmacol] 2025 Feb; Vol. 107 (2), pp. 100008. <i>Date of Electronic Publication: </i>2024 Dec 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0035623 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0111 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220026895X%22">0026895X </searchLink><i>NLM ISO Abbreviation: </i>Mol Pharmacol <i>Subsets: </i>MEDLINE
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              Text: 2025 Feb
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