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TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer.

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Title: TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer.
Authors: Lee JJW; Department of Otolaryngology-Head and Neck Surgery, Sinai Health System, Toronto, Ontario, Canada., Latif A; Department of Medical Microbiology and Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada., Scott EN; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Thakral A; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada., Mahler MB; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Brooks B; Audiology and Speech Pathology Department, BC Children's Hospital, Vancouver, British Columbia, Canada., Hueniken K; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada., Billfalk-Kelly A; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Espin-Garcia O; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada., Zhan LJ; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada., Rassekh SR; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, British Columbia, Canada., Pecheux L; Division of Pediatric Oncology, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada., Spavor M; Division of Pediatric Oncology, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada., Li Y; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Goldstein D; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Otolaryngology - Head and Neck Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada., Hope A; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Ross CJ; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Liu G; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address: geoffry.liu@uhn.ca., Carleton BC; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Electronic address: bcarleton@popi.ubc.ca., Bhavsar AP; Department of Medical Microbiology and Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address: amit.bhavsar@ualberta.ca.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2025 Feb; Vol. 392 (2), pp. 100057. Date of Electronic Publication: 2024 Dec 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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  Data: TLR4 downregulation protects against cisplatin-induced ototoxicity in adult and pediatric patients with cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lee+JJW%22">Lee JJW</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Sinai Health System, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Latif+A%22">Latif A</searchLink>; Department of Medical Microbiology and Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Scott+EN%22">Scott EN</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Thakral+A%22">Thakral A</searchLink>; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mahler+MB%22">Mahler MB</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Brooks+B%22">Brooks B</searchLink>; Audiology and Speech Pathology Department, BC Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Hueniken+K%22">Hueniken K</searchLink>; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Billfalk-Kelly+A%22">Billfalk-Kelly A</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Espin-Garcia+O%22">Espin-Garcia O</searchLink>; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zhan+LJ%22">Zhan LJ</searchLink>; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rassekh+SR%22">Rassekh SR</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Pecheux+L%22">Pecheux L</searchLink>; Division of Pediatric Oncology, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Spavor+M%22">Spavor M</searchLink>; Division of Pediatric Oncology, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Goldstein+D%22">Goldstein D</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Otolaryngology - Head and Neck Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hope+A%22">Hope A</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ross+CJ%22">Ross CJ</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address: geoffry.liu@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Carleton+BC%22">Carleton BC</searchLink>; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. Electronic address: bcarleton@popi.ubc.ca.<br /><searchLink fieldCode="AU" term="%22Bhavsar+AP%22">Bhavsar AP</searchLink>; Department of Medical Microbiology and Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada; Department of Pharmacology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address: amit.bhavsar@ualberta.ca.
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2025 Feb; Vol. 392 (2), pp. 100057. <i>Date of Electronic Publication: </i>2024 Dec 09.
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        Text: English
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