Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation.
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| Title: | Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation. |
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| Authors: | Griepke S; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Grentzmann A; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Tripodi GL; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Hansen J; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., da Fonseca MP; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Nilsson MD; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Tallouzi Y; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Grupe E; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Jensen PS; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Beck HC; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Temprano-Sagrera G; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain.; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Monforte de Lemos 3-5, Pabellón 11, Planta 028029, Madrid, Spain., Burton M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Dembic M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Forteza MJ; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden., Terp MG; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Lindholt JS; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense 5000, Denmark., Rasmussen LM; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Steffensen LB; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Stubbe J; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark., Ketelhuth DFJ; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark. |
| Source: | Cardiovascular research [Cardiovasc Res] 2025 Jul 31; Vol. 121 (8), pp. 1269-1281. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40037693 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Griepke+S%22">Griepke S</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Grentzmann+A%22">Grentzmann A</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Tripodi+GL%22">Tripodi GL</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+J%22">Hansen J</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22da+Fonseca+MP%22">da Fonseca MP</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Nilsson+MD%22">Nilsson MD</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Tallouzi+Y%22">Tallouzi Y</searchLink>; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Grupe+E%22">Grupe E</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+PS%22">Jensen PS</searchLink>; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Beck+HC%22">Beck HC</searchLink>; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Temprano-Sagrera+G%22">Temprano-Sagrera G</searchLink>; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain.<br /><searchLink fieldCode="AU" term="%22Sabater-Lleal+M%22">Sabater-Lleal M</searchLink>; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain.; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Monforte de Lemos 3-5, Pabellón 11, Planta 028029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Burton+M%22">Burton M</searchLink>; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Dembic+M%22">Dembic M</searchLink>; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Thomassen+M%22">Thomassen M</searchLink>; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Forteza+MJ%22">Forteza MJ</searchLink>; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Terp+MG%22">Terp MG</searchLink>; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Lindholt+JS%22">Lindholt JS</searchLink>; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Rasmussen+LM%22">Rasmussen LM</searchLink>; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Steffensen+LB%22">Steffensen LB</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Stubbe+J%22">Stubbe J</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.<br /><searchLink fieldCode="AU" term="%22Ketelhuth+DFJ%22">Ketelhuth DFJ</searchLink>; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220077427%22">Cardiovascular research</searchLink> [Cardiovasc Res] 2025 Jul 31; Vol. 121 (8), pp. 1269-1281. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+Journals%22">Oxford Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0077427 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-3245 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200086363%22">00086363 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Res <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40037693 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/cvr/cvaf032 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1269 Titles: – TitleFull: Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Griepke S – PersonEntity: Name: NameFull: Grentzmann A – PersonEntity: Name: NameFull: Tripodi GL – PersonEntity: Name: NameFull: Hansen J – PersonEntity: Name: NameFull: da Fonseca MP – PersonEntity: Name: NameFull: Nilsson MD – PersonEntity: Name: NameFull: Tallouzi Y – PersonEntity: Name: NameFull: Grupe E – PersonEntity: Name: NameFull: Jensen PS – PersonEntity: Name: NameFull: Beck HC – PersonEntity: Name: NameFull: Temprano-Sagrera G – PersonEntity: Name: NameFull: Sabater-Lleal M – PersonEntity: Name: NameFull: Burton M – PersonEntity: Name: NameFull: Dembic M – PersonEntity: Name: NameFull: Thomassen M – PersonEntity: Name: NameFull: Forteza MJ – PersonEntity: Name: NameFull: Terp MG – PersonEntity: Name: NameFull: Lindholt JS – PersonEntity: Name: NameFull: Rasmussen LM – PersonEntity: Name: NameFull: Steffensen LB – PersonEntity: Name: NameFull: Stubbe J – PersonEntity: Name: NameFull: Ketelhuth DFJ IsPartOfRelationships: – BibEntity: Dates: – D: 31 M: 07 Text: 2025 Jul 31 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1755-3245 Numbering: – Type: volume Value: 121 – Type: issue Value: 8 Titles: – TitleFull: Cardiovascular research Type: main |
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