Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation.
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| Title: | Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation. |
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| Authors: | Griepke S; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Grentzmann A; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Tripodi GL; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Hansen J; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., da Fonseca MP; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Nilsson MD; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Tallouzi Y; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Grupe E; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Jensen PS; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Beck HC; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Temprano-Sagrera G; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR SANT PAU), Sant Quintí 77-79, Barcelona 17 08041, Spain.; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Monforte de Lemos 3-5, Pabellón 11, Planta 028029, Madrid, Spain., Burton M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Dembic M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Thomassen M; Department of Clinical Genetics, Odense University Hospital, Odense 5000, Denmark.; Clinical Genome Center, University of Southern Denmark and Region of Southern Denmark, Odense 5000, Denmark., Forteza MJ; Center for Molecular Medicine, Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, BioClinicum, Solnavägen 30, Solna, 17 164 Stockholm, Sweden., Terp MG; Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Lindholt JS; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, Odense 5000, Denmark., Rasmussen LM; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark.; Department of Clinical Biochemistry, Odense University Hospital, Odense 5000, Denmark., Steffensen LB; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark., Stubbe J; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.; Elite Research Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, Odense 5000, Denmark., Ketelhuth DFJ; Cardiovascular and Renal Research Unit, Department of Molecular Medicine, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark. |
| Source: | Cardiovascular research [Cardiovasc Res] 2025 Jul 31; Vol. 121 (8), pp. 1269-1281. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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