Comparison of the in vivo efficacy and resistance development potential between cefiderocol and ceftolozane/tazobactam human simulated exposures against Pseudomonas aeruginosa in 72-hour murine thigh infection model.

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Title: Comparison of the in vivo efficacy and resistance development potential between cefiderocol and ceftolozane/tazobactam human simulated exposures against Pseudomonas aeruginosa in 72-hour murine thigh infection model.
Authors: Fouad A; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA., Nicolau SE; mRNA Center of Excellence, Sanofi Pasteur, Waltham, MA, USA., Tamma PD; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Simner PJ; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA., Gill CM; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.
Source: Infectious diseases (London, England) [Infect Dis (Lond)] 2025 Jul; Vol. 57 (7), pp. 658-668. Date of Electronic Publication: 2025 Mar 05.
Publication Type: Journal Article; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101650235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2374-4243 (Electronic) Linking ISSN: 23744243 NLM ISO Abbreviation: Infect Dis (Lond) Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2374-4243
DOI:10.1080/23744235.2025.2471822