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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.

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Bibliographic Details
Title: Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.
Authors: Cregg J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Edwards AV; Revolution Medicines, Inc., Redwood City, California 94063, United States., Chang S; Revolution Medicines, Inc., Redwood City, California 94063, United States., Lee BJ; Revolution Medicines, Inc., Redwood City, California 94063, United States., Knox JE; Revolution Medicines, Inc., Redwood City, California 94063, United States., Tomlinson ACA; Revolution Medicines, Inc., Redwood City, California 94063, United States., Marquez A; Revolution Medicines, Inc., Redwood City, California 94063, United States., Liu Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Freilich R; Revolution Medicines, Inc., Redwood City, California 94063, United States., Aay N; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Y; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang L; Revolution Medicines, Inc., Redwood City, California 94063, United States., Jiang J; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Flagella M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wildes D; Revolution Medicines, Inc., Redwood City, California 94063, United States., Smith JAM; Revolution Medicines, Inc., Redwood City, California 94063, United States., Singh M; Revolution Medicines, Inc., Redwood City, California 94063, United States., Wang Z; Revolution Medicines, Inc., Redwood City, California 94063, United States., Gill AL; Revolution Medicines, Inc., Redwood City, California 94063, United States., Koltun ES; Revolution Medicines, Inc., Redwood City, California 94063, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Mar 27; Vol. 68 (6), pp. 6064-6083. Date of Electronic Publication: 2025 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.4c02314