Gene dosage architecture across complex traits.

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Bibliographic Details
Title: Gene dosage architecture across complex traits.
Authors: Kazem S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Kumar K; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Jean-Louis M; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Huguet G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Renne T; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Saci Z; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Engchuan W; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Shanta O; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Thiruvahindrapuram B; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., MacDonald JR; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Greenwood CMT; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Scherer SW; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Almasy L; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Sebat J; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Glahn DC; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Dumas G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Jacquemont S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Feb 26. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.02.25.25322833