Gene dosage architecture across complex traits.

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Title: Gene dosage architecture across complex traits.
Authors: Kazem S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Kumar K; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Jean-Louis M; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Huguet G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Renne T; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Saci Z; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Engchuan W; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Shanta O; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Thiruvahindrapuram B; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., MacDonald JR; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Greenwood CMT; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Scherer SW; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Almasy L; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Sebat J; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Glahn DC; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Dumas G; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada., Jacquemont S; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Feb 26. Date of Electronic Publication: 2025 Feb 26.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
An: 40061331
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Gene dosage architecture across complex traits.
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Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Jean-Louis+M%22">Jean-Louis M</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Huguet+G%22">Huguet G</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; 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Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Thiruvahindrapuram+B%22">Thiruvahindrapuram B</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22MacDonald+JR%22">MacDonald JR</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; 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Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Sebat+J%22">Sebat J</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Glahn+DC%22">Glahn DC</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Dumas+G%22">Dumas G</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Jacquemont+S%22">Jacquemont S</searchLink>; Centre de recherche Azrieli, CHU Sainte-Justine and University of Montréal, Canada.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, PA, USA.; Lifespan Brain Institute, Children's Hospital of Philadelphia and Penn Medicine, PA, USA.; Department of Genetics, University of Pennsylvania, PA, USA.; Harvard Medical School, Department of Psychiatry, 25 Shattuck St, Boston, MA, USA.; Boston Children's Hospital, Tommy Fuss Center for Neuropsychiatric Disease Research, 300 Longwood Avenue, Boston, MA, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.; Mila - Quebec AI Institute, University of Montréal, Canada.
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      – TitleFull: Gene dosage architecture across complex traits.
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            NameFull: Glahn DC
      – PersonEntity:
          Name:
            NameFull: Dumas G
      – PersonEntity:
          Name:
            NameFull: Jacquemont S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 02
              Text: 2025 Feb 26
              Type: published
              Y: 2025
          Titles:
            – TitleFull: MedRxiv : the preprint server for health sciences
              Type: main
ResultId 1