Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.

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Title: Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection.
Authors: Hurst JH; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Mohan AA; Department of Biomedical Engineering, Duke University School of Medicine, Durham, NC, USA., Dalapati T; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., George IA; Duke University School of Medicine, Durham, NC, USA., Aquino JN; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Lugo DJ; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Pfeiffer TS; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Rodriguez J; Children's Clinical Research Unit, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA., Rotta AT; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University School of Medicine, Durham, NC, USA., Turner NA; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA., Burke TW; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA., McClain MT; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA., Henao R; Department of Biostatistics and Informatics, Duke University, Durham, NC, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., DeMarco CT; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Louzao R; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Denny TN; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Walsh KM; Children's Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Xu Z; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Mejias A; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Ramilo O; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA., Woods CW; Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA.; Center for Infectious Disease Diagnostics and Innovation, Duke University School of Medicine, Durham, NC, USA.; Durham Veterans Affairs Medical Center, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA., Kelly MS; Department of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA. mkelly3@uams.edu.
Source: Nature communications [Nat Commun] 2025 Mar 10; Vol. 16 (1), pp. 2383. Date of Electronic Publication: 2025 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-57655-3