A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
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| Title: | A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis. |
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| Authors: | Nangle LA; aTyr Pharma, San Diego, CA 92121, USA., Xu Z; aTyr Pharma, San Diego, CA 92121, USA., Siefker D; aTyr Pharma, San Diego, CA 92121, USA., Burkart C; aTyr Pharma, San Diego, CA 92121, USA., Chong YE; aTyr Pharma, San Diego, CA 92121, USA., Zhai L; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Geng Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Polizzi C; aTyr Pharma, San Diego, CA 92121, USA., Guy L; aTyr Pharma, San Diego, CA 92121, USA., Eide L; aTyr Pharma, San Diego, CA 92121, USA., Tong Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Klopp-Savino S; aTyr Pharma, San Diego, CA 92121, USA., Ferrer M; aTyr Pharma, San Diego, CA 92121, USA., Rauch K; aTyr Pharma, San Diego, CA 92121, USA., Wang A; aTyr Pharma, San Diego, CA 92121, USA., Hamel K; aTyr Pharma, San Diego, CA 92121, USA., Crampton S; aTyr Pharma, San Diego, CA 92121, USA., Paz S; aTyr Pharma, San Diego, CA 92121, USA., Chiang KP; aTyr Pharma, San Diego, CA 92121, USA., Do MH; aTyr Pharma, San Diego, CA 92121, USA., Burman L; aTyr Pharma, San Diego, CA 92121, USA., Lee D; aTyr Pharma, San Diego, CA 92121, USA., Zhang M; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Ogilvie K; aTyr Pharma, San Diego, CA 92121, USA., King D; aTyr Pharma, San Diego, CA 92121, USA., Adams RA; aTyr Pharma, San Diego, CA 92121, USA., Schimmel P; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2025 Mar 12; Vol. 17 (789), pp. eadp4754. Date of Electronic Publication: 2025 Mar 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adp4754 |
