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A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.

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Title: A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
Authors: Nangle LA; aTyr Pharma, San Diego, CA 92121, USA., Xu Z; aTyr Pharma, San Diego, CA 92121, USA., Siefker D; aTyr Pharma, San Diego, CA 92121, USA., Burkart C; aTyr Pharma, San Diego, CA 92121, USA., Chong YE; aTyr Pharma, San Diego, CA 92121, USA., Zhai L; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Geng Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Polizzi C; aTyr Pharma, San Diego, CA 92121, USA., Guy L; aTyr Pharma, San Diego, CA 92121, USA., Eide L; aTyr Pharma, San Diego, CA 92121, USA., Tong Y; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China., Klopp-Savino S; aTyr Pharma, San Diego, CA 92121, USA., Ferrer M; aTyr Pharma, San Diego, CA 92121, USA., Rauch K; aTyr Pharma, San Diego, CA 92121, USA., Wang A; aTyr Pharma, San Diego, CA 92121, USA., Hamel K; aTyr Pharma, San Diego, CA 92121, USA., Crampton S; aTyr Pharma, San Diego, CA 92121, USA., Paz S; aTyr Pharma, San Diego, CA 92121, USA., Chiang KP; aTyr Pharma, San Diego, CA 92121, USA., Do MH; aTyr Pharma, San Diego, CA 92121, USA., Burman L; aTyr Pharma, San Diego, CA 92121, USA., Lee D; aTyr Pharma, San Diego, CA 92121, USA., Zhang M; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China., Ogilvie K; aTyr Pharma, San Diego, CA 92121, USA., King D; aTyr Pharma, San Diego, CA 92121, USA., Adams RA; aTyr Pharma, San Diego, CA 92121, USA., Schimmel P; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Mar 12; Vol. 17 (789), pp. eadp4754. Date of Electronic Publication: 2025 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Nangle+LA%22">Nangle LA</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Siefker+D%22">Siefker D</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Burkart+C%22">Burkart C</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Chong+YE%22">Chong YE</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Zhai+L%22">Zhai L</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Geng+Y%22">Geng Y</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Polizzi+C%22">Polizzi C</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Guy+L%22">Guy L</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Eide+L%22">Eide L</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Tong+Y%22">Tong Y</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.; Pangu Biopharma, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Klopp-Savino+S%22">Klopp-Savino S</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Ferrer+M%22">Ferrer M</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Rauch+K%22">Rauch K</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Hamel+K%22">Hamel K</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Crampton+S%22">Crampton S</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Paz+S%22">Paz S</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Chiang+KP%22">Chiang KP</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Do+MH%22">Do MH</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Burman+L%22">Burman L</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; IAS HKUST-Scripps R&D Laboratory, Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Ogilvie+K%22">Ogilvie K</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22King+D%22">King D</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Adams+RA%22">Adams RA</searchLink>; aTyr Pharma, San Diego, CA 92121, USA.<br /><searchLink fieldCode="AU" term="%22Schimmel+P%22">Schimmel P</searchLink>; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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