Label-free Aβ plaque detection in Alzheimer's disease brain tissue using infrared microscopy and neural networks.

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Title: Label-free Aβ plaque detection in Alzheimer's disease brain tissue using infrared microscopy and neural networks.
Authors: Müller D; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Bioinformatics Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Bioinformatics, Germany., Röhr D; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Biospectroscopy Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Biophysics, Germany., Boon BDC; Amsterdam UMC, Amsterdam Neuroscience, Department of Pathology, the Netherlands.; Mayo Clinic, Department of Neuroscience, Jacksonville, FL, USA., Wulf M; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Medical Proteome Analysis, Germany.; Ruhr University Bochum, Faculty of Medicine, Medizinisches Proteom-Center, Germany., Arto T; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Biospectroscopy Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Biophysics, Germany., Hoozemans JJM; Amsterdam UMC, Amsterdam Neuroscience, Department of Pathology, the Netherlands., Marcus K; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Medical Proteome Analysis, Germany.; Ruhr University Bochum, Faculty of Medicine, Medizinisches Proteom-Center, Germany., Rozemuller AJM; Amsterdam UMC, Amsterdam Neuroscience, Department of Pathology, the Netherlands., Großerueschkamp F; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Biospectroscopy Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Biophysics, Germany., Mosig A; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Bioinformatics Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Bioinformatics, Germany., Gerwert K; Ruhr University Bochum, Center for Protein Diagnostics (PRODI), Biospectroscopy Division, Germany.; Ruhr University Bochum, Faculty of Biology and Biotechnology, Department of Biophysics, Germany.
Source: Heliyon [Heliyon] 2025 Jan 18; Vol. 11 (4), pp. e42111. Date of Electronic Publication: 2025 Jan 18 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2405-8440
DOI:10.1016/j.heliyon.2025.e42111