APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.
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| Title: | APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons. |
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| Authors: | Skrajna A; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA., Bodrug T; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Martinez-Chacin RC; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Pharmacology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Fisher CB; Department of Biochemistry and Biophysics, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Welsh KA; Department of Pharmacology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Simmons HC; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Arteaga EC; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Simmons JM; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.; Department of Biochemistry and Biophysics, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Nasr MA; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA., LaPak KM; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Nguyen A; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Huynh MT; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Fargo I; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Welfare JG; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Zhao Y; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Lawrence DS; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA.; Department of Pharmacology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA.; Department of Chemistry, University of North Carolina, Chapel Hill, NC, USA., Goldfarb D; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA.; Institute for Informatics, Washington University School of Medicine, St. Louis, MO, USA., Brown NG; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. nbrown1@med.unc.edu.; Department of Pharmacology, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA. nbrown1@med.unc.edu., McGinty RK; Division of Chemical Biology and Medicinal Chemistry and Center for Integrated Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. rmcginty@email.unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. rmcginty@email.unc.edu.; Department of Biochemistry and Biophysics, UNC School of Medicine, University of North Carolina, Chapel Hill, NC, USA. rmcginty@email.unc.edu. |
| Source: | Nature communications [Nat Commun] 2025 Mar 15; Vol. 16 (1), pp. 2561. Date of Electronic Publication: 2025 Mar 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-57384-7 |
