Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.

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Title: Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.
Authors: Cobo I; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; CAMBAC (Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center), University of Alabama at Birmingham, Birmingham, CA, USA. Electronic address: isidorocobo@uabmc.edu., Murillo-Saich J; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Alishala M; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Calderon S; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Coras R; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Hemming B; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Inkum F; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Rosas F; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Takei R; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Spann N; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Prohaska TA; Department of Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Alabarse PVG; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA., Jeong SJ; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Nickl CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Cheng A; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Li B; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Vogel A; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria., Weichhart T; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria., Fuster JJ; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; CIBER en Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain., Le T; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Bradstreet TR; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Webber AM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Edelson BT; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Razani B; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA; Division of Cardiology, Pittsburgh VA Medical Center, Pittsburgh, PA, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA., Taneja R; Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Terkeltaub R; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA., Bryan RL; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA., Guma M; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA; Department of Medicine, Autonomous University of Barcelona, Plaça Cívica, Bellaterra, Barcelona 08193, Spain., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA. Electronic address: cglass@health.ucsd.edu.
Source: Immunity [Immunity] 2025 Apr 08; Vol. 58 (4), pp. 826-842.e8. Date of Electronic Publication: 2025 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2025.02.023