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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.

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Title: Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.
Authors: Cobo I; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; CAMBAC (Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center), University of Alabama at Birmingham, Birmingham, CA, USA. Electronic address: isidorocobo@uabmc.edu., Murillo-Saich J; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Alishala M; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Calderon S; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Coras R; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Hemming B; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Inkum F; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Rosas F; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Takei R; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Spann N; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Prohaska TA; Department of Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Alabarse PVG; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA., Jeong SJ; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Nickl CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Cheng A; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA., Li B; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Vogel A; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria., Weichhart T; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria., Fuster JJ; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; CIBER en Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain., Le T; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA., Bradstreet TR; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Webber AM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Edelson BT; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Razani B; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA; Division of Cardiology, Pittsburgh VA Medical Center, Pittsburgh, PA, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA., Taneja R; Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Terkeltaub R; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA., Bryan RL; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA., Guma M; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA; Department of Medicine, Autonomous University of Barcelona, Plaça Cívica, Bellaterra, Barcelona 08193, Spain., Glass CK; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA. Electronic address: cglass@health.ucsd.edu.
Source: Immunity [Immunity] 2025 Apr 08; Vol. 58 (4), pp. 826-842.e8. Date of Electronic Publication: 2025 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.
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  Data: <searchLink fieldCode="AU" term="%22Cobo+I%22">Cobo I</searchLink>; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; CAMBAC (Comprehensive Arthritis, Musculoskeletal, Bone and Autoimmunity Center), University of Alabama at Birmingham, Birmingham, CA, USA. Electronic address: isidorocobo@uabmc.edu.<br /><searchLink fieldCode="AU" term="%22Murillo-Saich+J%22">Murillo-Saich J</searchLink>; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alishala+M%22">Alishala M</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Calderon+S%22">Calderon S</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Coras+R%22">Coras R</searchLink>; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hemming+B%22">Hemming B</searchLink>; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Inkum+F%22">Inkum F</searchLink>; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Rosas+F%22">Rosas F</searchLink>; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Takei+R%22">Takei R</searchLink>; Division of Clinical Immunology & Rheumatology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Spann+N%22">Spann N</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Prohaska+TA%22">Prohaska TA</searchLink>; Department of Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Alabarse+PVG%22">Alabarse PVG</searchLink>; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.<br /><searchLink fieldCode="AU" term="%22Jeong+SJ%22">Jeong SJ</searchLink>; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Nickl+CK%22">Nickl CK</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+A%22">Cheng A</searchLink>; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vogel+A%22">Vogel A</searchLink>; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Weichhart+T%22">Weichhart T</searchLink>; Center for Pathobiochemistry & Genetics, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Fuster+JJ%22">Fuster JJ</searchLink>; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; CIBER en Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Le+T%22">Le T</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bradstreet+TR%22">Bradstreet TR</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Webber+AM%22">Webber AM</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Edelson+BT%22">Edelson BT</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Razani+B%22">Razani B</searchLink>; Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA; Division of Cardiology, Pittsburgh VA Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Taneja+R%22">Taneja R</searchLink>; Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Terkeltaub+R%22">Terkeltaub R</searchLink>; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Bryan+RL%22">Bryan RL</searchLink>; VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.<br /><searchLink fieldCode="AU" term="%22Guma+M%22">Guma M</searchLink>; Division of Rheumatology, Allergy, and Immunology, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, San Diego, CA, USA; Department of Medicine, Autonomous University of Barcelona, Plaça Cívica, Bellaterra, Barcelona 08193, Spain.<br /><searchLink fieldCode="AU" term="%22Glass+CK%22">Glass CK</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, San Diego, CA, USA. Electronic address: cglass@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2025 Apr 08; Vol. 58 (4), pp. 826-842.e8. <i>Date of Electronic Publication: </i>2025 Mar 20.
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