Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.

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Title: Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Authors: Tursi NJ; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tiwari S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bedanova N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kannan T; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Parzych E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Okba N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Liaw K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Sárközy A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Livingston C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Trullen MI; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gary EN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Vadovics M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Laenger N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Biology Department, Saint Joseph's University, Philadelphia, PA 19131, USA., Londregan J; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Khan MS; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Omo-Lamai S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Blatney K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Hojecki C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Machado V; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Humeau LM; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kossenkov A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Allman D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pnorbert@pennmedicine.upenn.edu., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dweiner@wistar.org.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102035. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-3791
DOI:10.1016/j.xcrm.2025.102035