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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.

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Title: Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Authors: Tursi NJ; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tiwari S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bedanova N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kannan T; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Parzych E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Okba N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Liaw K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Sárközy A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Livingston C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Trullen MI; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gary EN; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Vadovics M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Laenger N; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Biology Department, Saint Joseph's University, Philadelphia, PA 19131, USA., Londregan J; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Khan MS; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Omo-Lamai S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Muramatsu H; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Blatney K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Hojecki C; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Machado V; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Humeau LM; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Kossenkov A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA., Brenner JS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Allman D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria., Pardi N; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pnorbert@pennmedicine.upenn.edu., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dweiner@wistar.org.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102035. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
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  Data: <searchLink fieldCode="AU" term="%22Tursi+NJ%22">Tursi NJ</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+S%22">Tiwari S</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Bedanova+N%22">Bedanova N</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kannan+T%22">Kannan T</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Parzych+E%22">Parzych E</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Okba+N%22">Okba N</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Liaw+K%22">Liaw K</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Sárközy+A%22">Sárközy A</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Livingston+C%22">Livingston C</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Trullen+MI%22">Trullen MI</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Gary+EN%22">Gary EN</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Vadovics+M%22">Vadovics M</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Laenger+N%22">Laenger N</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA; Biology Department, Saint Joseph's University, Philadelphia, PA 19131, USA.<br /><searchLink fieldCode="AU" term="%22Londregan+J%22">Londregan J</searchLink>; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Khan+MS%22">Khan MS</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Omo-Lamai+S%22">Omo-Lamai S</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Muramatsu+H%22">Muramatsu H</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Blatney+K%22">Blatney K</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Hojecki+C%22">Hojecki C</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Machado+V%22">Machado V</searchLink>; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA.<br /><searchLink fieldCode="AU" term="%22Maricic+I%22">Maricic I</searchLink>; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA.<br /><searchLink fieldCode="AU" term="%22Smith+TRF%22">Smith TRF</searchLink>; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA.<br /><searchLink fieldCode="AU" term="%22Humeau+LM%22">Humeau LM</searchLink>; Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA.<br /><searchLink fieldCode="AU" term="%22Patel+A%22">Patel A</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Kossenkov+A%22">Kossenkov A</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Brenner+JS%22">Brenner JS</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Allman+D%22">Allman D</searchLink>; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Krammer+F%22">Krammer F</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pardi+N%22">Pardi N</searchLink>; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: pnorbert@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Weiner+DB%22">Weiner DB</searchLink>; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dweiner@wistar.org.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2025 Apr 15; Vol. 6 (4), pp. 102035. <i>Date of Electronic Publication: </i>2025 Mar 21.
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