Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer.
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| Title: | Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer. |
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| Authors: | Burckel H; Radiobiology Laboratory, Paul Strauss Comprehensive, Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), UNICANCER, 67000, Strasbourg, France. h.burckel@icans.eu.; Equipe Imagerie Multimodale Intégrative en Santé, ICube, UMR7357, Université de Strasbourg, Strasbourg, France. h.burckel@icans.eu., Nicol A; Radiobiology Laboratory, Paul Strauss Comprehensive, Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), UNICANCER, 67000, Strasbourg, France.; Equipe Imagerie Multimodale Intégrative en Santé, ICube, UMR7357, Université de Strasbourg, Strasbourg, France., Mura C; Radiobiology Laboratory, Paul Strauss Comprehensive, Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), UNICANCER, 67000, Strasbourg, France.; Equipe Imagerie Multimodale Intégrative en Santé, ICube, UMR7357, Université de Strasbourg, Strasbourg, France., Rousseau M; Institut Pluridisciplinaire Hubert Curien, Université de Strasbourg, CNRS, UMR 7178, 67200, Strasbourg, France., Bou-Gharios J; Radiobiology Laboratory, Paul Strauss Comprehensive, Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), UNICANCER, 67000, Strasbourg, France.; Equipe Imagerie Multimodale Intégrative en Santé, ICube, UMR7357, Université de Strasbourg, Strasbourg, France., Froidurot L; X-Rain: Research Unit in Radiotherapy Combined with Immunotherapies and Nanoparticles, IMATHERA, Department of Radiation Oncology, Unicancer-Georges-Francois Leclerc Cancer Center, 21000, Dijon, France., Richard C; Molecular Biology Clinical Research, Unicancer-Center Georges-Francois Leclerc, 21000, Dijon, France., Morgand V; X-Rain: Research Unit in Radiotherapy Combined with Immunotherapies and Nanoparticles, IMATHERA, Department of Radiation Oncology, Unicancer-Georges-Francois Leclerc Cancer Center, 21000, Dijon, France., Laurent PA; X-Rain: Research Unit in Radiotherapy Combined with Immunotherapies and Nanoparticles, IMATHERA, Department of Radiation Oncology, Unicancer-Georges-Francois Leclerc Cancer Center, 21000, Dijon, France., Limagne E; CTM, INSERM, UMR 1231, Trecs Team, CTM, 21000, Dijon, France.; PTBC, CGFL, Dijon, France., Boidot R; Molecular Biology Clinical Research, Unicancer-Center Georges-Francois Leclerc, 21000, Dijon, France., Noël G; Radiobiology Laboratory, Paul Strauss Comprehensive, Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), UNICANCER, 67000, Strasbourg, France.; Equipe Imagerie Multimodale Intégrative en Santé, ICube, UMR7357, Université de Strasbourg, Strasbourg, France.; Institut de Cancérologie Strasbourg Europe (ICANS), Paul Strauss Comprehensive Cancer Center, Department of Radiation Oncology, UNICANCER, 17 Rue Albert Calmette, 67200, Strasbourg, France., Mirjolet C; X-Rain: Research Unit in Radiotherapy Combined with Immunotherapies and Nanoparticles, IMATHERA, Department of Radiation Oncology, Unicancer-Georges-Francois Leclerc Cancer Center, 21000, Dijon, France.; CTM, INSERM, UMR 1231, Trecs Team, CTM, 21000, Dijon, France. |
| Source: | Journal of translational medicine [J Transl Med] 2025 Mar 23; Vol. 23 (1), pp. 360. Date of Electronic Publication: 2025 Mar 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1479-5876 |
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| DOI: | 10.1186/s12967-025-06377-7 |
