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Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone.

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Title: Anopheles mosquito survival and pharmacokinetic modeling show the mosquitocidal activity of nitisinone.
Authors: Haines LR; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Trett A; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Rose C; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK., García N; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Sterkel M; Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CENEXA, CONICET, La Plata, Argentina., McGuinness D; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Regnault C; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.; Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Barrett MP; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.; Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Leroy D; Medicines for Malaria Venture, Geneva, Switzerland., Burrows JN; Medicines for Malaria Venture, Geneva, Switzerland.; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Biagini G; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Ranganath LR; National Alkaptonuria Centre, Department of Clinical Biochemistry and Metabolism, Royal Liverpool University Hospital, Liverpool, UK., Aljayyoussi G; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK., Acosta-Serrano Á; Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Source: Science translational medicine [Sci Transl Med] 2025 Mar 26; Vol. 17 (791), pp. eadr4827. Date of Electronic Publication: 2025 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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