View in EDS HTML Full Text PDF Full Text

CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.

Saved in:
Bibliographic Details
Title: CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.
Authors: Salzler R; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., DiLillo DJ; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Saotome K; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Bray K; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Mohrs K; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Hwang H; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Cygan KJ; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Shah D; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Rye-Weller A; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Kundu K; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Badithe A; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Zhang X; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Garnova E; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Torres M; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Dhanik A; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Babb R; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Delfino FJ; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Thwaites C; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Dudgeon D; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Moore MJ; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Meagher TC; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Decker CE; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Owczarek T; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Gleason JA; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Yang X; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Suh D; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Lee WY; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Welsh R; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., MacDonald D; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Hansen J; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Guo C; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Kirshner JR; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Thurston G; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Huang T; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Franklin MC; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Yancopoulos GD; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Lin JC; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Macdonald LE; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Murphy AJ; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Chen G; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Olsen O; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA., Olson WC; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Mar 26; Vol. 17 (791), pp. eado9371. Date of Electronic Publication: 2025 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40138458
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Salzler+R%22">Salzler R</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22DiLillo+DJ%22">DiLillo DJ</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Saotome+K%22">Saotome K</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Bray+K%22">Bray K</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Mohrs+K%22">Mohrs K</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+H%22">Hwang H</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Cygan+KJ%22">Cygan KJ</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Shah+D%22">Shah D</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Rye-Weller+A%22">Rye-Weller A</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Kundu+K%22">Kundu K</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Badithe+A%22">Badithe A</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Garnova+E%22">Garnova E</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Torres+M%22">Torres M</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Dhanik+A%22">Dhanik A</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Babb+R%22">Babb R</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Delfino+FJ%22">Delfino FJ</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Thwaites+C%22">Thwaites C</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Dudgeon+D%22">Dudgeon D</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Moore+MJ%22">Moore MJ</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Meagher+TC%22">Meagher TC</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Decker+CE%22">Decker CE</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Owczarek+T%22">Owczarek T</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Gleason+JA%22">Gleason JA</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Suh+D%22">Suh D</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WY%22">Lee WY</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Welsh+R%22">Welsh R</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22MacDonald+D%22">MacDonald D</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Hansen+J%22">Hansen J</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Kirshner+JR%22">Kirshner JR</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Thurston+G%22">Thurston G</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Franklin+MC%22">Franklin MC</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Yancopoulos+GD%22">Yancopoulos GD</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Macdonald+LE%22">Macdonald LE</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+AJ%22">Murphy AJ</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Olsen+O%22">Olsen O</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.<br /><searchLink fieldCode="AU" term="%22Olson+WC%22">Olson WC</searchLink>; Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Mar 26; Vol. 17 (791), pp. eado9371. <i>Date of Electronic Publication: </i>2025 Mar 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40138458
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scitranslmed.ado9371
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: eado9371
    Titles:
      – TitleFull: CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Salzler R
      – PersonEntity:
          Name:
            NameFull: DiLillo DJ
      – PersonEntity:
          Name:
            NameFull: Saotome K
      – PersonEntity:
          Name:
            NameFull: Bray K
      – PersonEntity:
          Name:
            NameFull: Mohrs K
      – PersonEntity:
          Name:
            NameFull: Hwang H
      – PersonEntity:
          Name:
            NameFull: Cygan KJ
      – PersonEntity:
          Name:
            NameFull: Shah D
      – PersonEntity:
          Name:
            NameFull: Rye-Weller A
      – PersonEntity:
          Name:
            NameFull: Kundu K
      – PersonEntity:
          Name:
            NameFull: Badithe A
      – PersonEntity:
          Name:
            NameFull: Zhang X
      – PersonEntity:
          Name:
            NameFull: Garnova E
      – PersonEntity:
          Name:
            NameFull: Torres M
      – PersonEntity:
          Name:
            NameFull: Dhanik A
      – PersonEntity:
          Name:
            NameFull: Babb R
      – PersonEntity:
          Name:
            NameFull: Delfino FJ
      – PersonEntity:
          Name:
            NameFull: Thwaites C
      – PersonEntity:
          Name:
            NameFull: Dudgeon D
      – PersonEntity:
          Name:
            NameFull: Moore MJ
      – PersonEntity:
          Name:
            NameFull: Meagher TC
      – PersonEntity:
          Name:
            NameFull: Decker CE
      – PersonEntity:
          Name:
            NameFull: Owczarek T
      – PersonEntity:
          Name:
            NameFull: Gleason JA
      – PersonEntity:
          Name:
            NameFull: Yang X
      – PersonEntity:
          Name:
            NameFull: Suh D
      – PersonEntity:
          Name:
            NameFull: Lee WY
      – PersonEntity:
          Name:
            NameFull: Welsh R
      – PersonEntity:
          Name:
            NameFull: MacDonald D
      – PersonEntity:
          Name:
            NameFull: Hansen J
      – PersonEntity:
          Name:
            NameFull: Guo C
      – PersonEntity:
          Name:
            NameFull: Kirshner JR
      – PersonEntity:
          Name:
            NameFull: Thurston G
      – PersonEntity:
          Name:
            NameFull: Huang T
      – PersonEntity:
          Name:
            NameFull: Franklin MC
      – PersonEntity:
          Name:
            NameFull: Yancopoulos GD
      – PersonEntity:
          Name:
            NameFull: Lin JC
      – PersonEntity:
          Name:
            NameFull: Macdonald LE
      – PersonEntity:
          Name:
            NameFull: Murphy AJ
      – PersonEntity:
          Name:
            NameFull: Chen G
      – PersonEntity:
          Name:
            NameFull: Olsen O
      – PersonEntity:
          Name:
            NameFull: Olson WC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 03
              Text: 2025 Mar 26
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1946-6242
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 791
          Titles:
            – TitleFull: Science translational medicine
              Type: main
ResultId 1