Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission.

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Title: Huperzine A attenuates epileptic seizures via enhancing dCA1-projecting septal cholinergic transmission.
Authors: Wang Y; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Hu KY; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Zhang QY; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Song YJ; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Li LJ; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Wang F; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Tian G; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Fei F; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China.; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences & The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China., Xu CL; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Fang JJ; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences & The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China., Jiang XH; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Wu JN; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Li WL; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China., Wang Y; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China. wang-yi@zju.edu.cn.; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences & The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China. wang-yi@zju.edu.cn., Chen Z; Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences & The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310053, China. chenzhong@zju.edu.cn.; Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences & The Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, China. chenzhong@zju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Aug; Vol. 46 (8), pp. 2151-2162. Date of Electronic Publication: 2025 Mar 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1745-7254
DOI:10.1038/s41401-025-01522-w