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A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.

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Title: A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.
Authors: Martinez-Rivas G; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Ayala MV; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Bender S; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Codo GR; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Swiderska WK; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Lampis A; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Pedroza L; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany., Merdanovic M; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany., Sicard P; PhyMedExp, IPAM/Biocampus (IBiSa/France Life Imaging), UMR INSERM 1046-CNRS 9214, universityof Montpellier, Montpellier, France., Pinault E; BISCEm (Biologie Intégrative Santé Chimie Environnement) Platform, US 42 INSERM/UAR 2015 CNRS, University of Limoges, Limoges, France., Richard L; Department of Pathology, University Hospital, Limoges, France., Lavatelli F; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Pavia, Italy.; Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Giorgetti S; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Pavia, Italy.; Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Canetti D; Centre for Amyloidosis, Division of Medicine, University College London, London, UK., Rinsant A; Department of Pathology, University Hospital, Poitiers, France., Kaaki S; Department of Pathology, University Hospital, Poitiers, France., Ory C; Department of Pathology, University Hospital, Poitiers, France., Oblet C; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France., Pollet J; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France., Naser E; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany., Carpinteiro A; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany., Roussel M; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Javaugue V; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.; Department of Nephrology, University Hospital, Poitiers, France., Jaccard A; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Bonaud A; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Delpy L; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France., Ehrmann M; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany., Bridoux F; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.; Department of Nephrology, University Hospital, Poitiers, France., Sirac C; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France. christophe.sirac@unilim.fr.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France. christophe.sirac@unilim.fr.
Source: Nature communications [Nat Commun] 2025 Mar 27; Vol. 16 (1), pp. 2992. Date of Electronic Publication: 2025 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.
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  Data: <searchLink fieldCode="AU" term="%22Martinez-Rivas+G%22">Martinez-Rivas G</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Ayala+MV%22">Ayala MV</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Bender+S%22">Bender S</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Codo+GR%22">Codo GR</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Swiderska+WK%22">Swiderska WK</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Lampis+A%22">Lampis A</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Pedroza+L%22">Pedroza L</searchLink>; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Merdanovic+M%22">Merdanovic M</searchLink>; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Sicard+P%22">Sicard P</searchLink>; PhyMedExp, IPAM/Biocampus (IBiSa/France Life Imaging), UMR INSERM 1046-CNRS 9214, universityof Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Pinault+E%22">Pinault E</searchLink>; BISCEm (Biologie Intégrative Santé Chimie Environnement) Platform, US 42 INSERM/UAR 2015 CNRS, University of Limoges, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Richard+L%22">Richard L</searchLink>; Department of Pathology, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Lavatelli+F%22">Lavatelli F</searchLink>; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Pavia, Italy.; Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgetti+S%22">Giorgetti S</searchLink>; Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Pavia, Italy.; Research Area, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Canetti+D%22">Canetti D</searchLink>; Centre for Amyloidosis, Division of Medicine, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rinsant+A%22">Rinsant A</searchLink>; Department of Pathology, University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Kaaki+S%22">Kaaki S</searchLink>; Department of Pathology, University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Ory+C%22">Ory C</searchLink>; Department of Pathology, University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Oblet+C%22">Oblet C</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Pollet+J%22">Pollet J</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Naser+E%22">Naser E</searchLink>; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Carpinteiro+A%22">Carpinteiro A</searchLink>; Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Roussel+M%22">Roussel M</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Javaugue+V%22">Javaugue V</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.; Department of Nephrology, University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Jaccard+A%22">Jaccard A</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Bonaud+A%22">Bonaud A</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Delpy+L%22">Delpy L</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Ehrmann+M%22">Ehrmann M</searchLink>; University Duisburg-Essen, Centre for Medical Biotechnology, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Bridoux+F%22">Bridoux F</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France.; Department of Nephrology, University Hospital, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Sirac+C%22">Sirac C</searchLink>; CNRS UMR7276/INSERM U1262, University of Limoges, CRIBL lab, team 3 BioPIC, Limoges, France. christophe.sirac@unilim.fr.; French National Reference Centre for AL Amyloidosis and Other Monoclonal IG Deposition Diseases, University Hospital, Limoges, France. christophe.sirac@unilim.fr.
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