The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.

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Title: The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.
Authors: Ohata Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Ali MM; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Tsubakihara Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Itoh Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan., Rosén G; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergström T; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Morén A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Golán-Cancela I; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Nakada A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Faculty of Pharmaceutical Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Voytyuk O; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Tsuchiya M; Department of Oral Pathology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.; Department of Pathology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Fukui R; Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan., Yamamoto K; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Martín-Rubio P; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain., Sancho P; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain., Strell C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Center for Cancer Biomarkers (CCBIO), Department of Clinical Medicine, University of Bergen, Bergen, Norway., Micke P; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Wechsler-Reya RJ; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Hashizume Y; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Saitama, Japan., Miyazono K; Department of Applied Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Caja L; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Heldin CH; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Swartling FJ; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Moustakas A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden. aris.moustakas@imbim.uu.se.
Source: Cell death and differentiation [Cell Death Differ] 2025 Oct; Vol. 32 (10), pp. 1915-1929. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5403
DOI:10.1038/s41418-025-01488-6