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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.

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Title: The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.
Authors: Ohata Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Ali MM; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Tsubakihara Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Itoh Y; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan., Rosén G; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Bergström T; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Morén A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Golán-Cancela I; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Nakada A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Faculty of Pharmaceutical Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Voytyuk O; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Tsuchiya M; Department of Oral Pathology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.; Department of Pathology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan., Fukui R; Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan., Yamamoto K; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Martín-Rubio P; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain., Sancho P; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain., Strell C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Center for Cancer Biomarkers (CCBIO), Department of Clinical Medicine, University of Bergen, Bergen, Norway., Micke P; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Wechsler-Reya RJ; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA., Hashizume Y; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Saitama, Japan., Miyazono K; Department of Applied Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Caja L; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Heldin CH; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden., Swartling FJ; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Moustakas A; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden. aris.moustakas@imbim.uu.se.
Source: Cell death and differentiation [Cell Death Differ] 2025 Oct; Vol. 32 (10), pp. 1915-1929. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
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  Data: The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Ohata+Y%22">Ohata Y</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ali+MM%22">Ali MM</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Tsubakihara+Y%22">Tsubakihara Y</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Itoh+Y%22">Itoh Y</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.<br /><searchLink fieldCode="AU" term="%22Rosén+G%22">Rosén G</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Bergström+T%22">Bergström T</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Morén+A%22">Morén A</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Golán-Cancela+I%22">Golán-Cancela I</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Nakada+A%22">Nakada A</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.; Faculty of Pharmaceutical Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Voytyuk+O%22">Voytyuk O</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Tsuchiya+M%22">Tsuchiya M</searchLink>; Department of Oral Pathology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.; Department of Pathology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukui+R%22">Fukui R</searchLink>; Department of Pathology, Nihon University School of Dentistry, Chiyoda-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Martín-Rubio+P%22">Martín-Rubio P</searchLink>; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Sancho+P%22">Sancho P</searchLink>; Translational Research Unit, Hospital Universitario Miguel Servet, IIS Aragon, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Strell+C%22">Strell C</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Center for Cancer Biomarkers (CCBIO), Department of Clinical Medicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Micke+P%22">Micke P</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Wechsler-Reya+RJ%22">Wechsler-Reya RJ</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hashizume+Y%22">Hashizume Y</searchLink>; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazono+K%22">Miyazono K</searchLink>; Department of Applied Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Caja+L%22">Caja L</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Heldin+CH%22">Heldin CH</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Swartling+FJ%22">Swartling FJ</searchLink>; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Moustakas+A%22">Moustakas A</searchLink>; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, Uppsala, Sweden. aris.moustakas@imbim.uu.se.
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