A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.

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Title:	A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.
Authors:	Ferhat L; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Soussi R; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Masse M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Kyriatzis G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Girard S; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Gassiot F; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Gaudin N; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Laurencin M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Bernard A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Bôle A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Ferracci G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Smirnova M; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France., Roman F; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Dive V; SIMOPRO CEA Saclay, Saclay, France., Cisternino S; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.; Pharmacie, Hôpital Universitaire Necker - Enfants Malades, AP-HP, Paris, France., Temsamani J; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., David M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Lécorché P; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Jacquot G; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Khrestchatisky M; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.
Source:	ELife [Elife] 2025 Mar 28; Vol. 13. Date of Electronic Publication: 2025 Mar 28.
Publication Type:	Journal Article
Journal Info:	Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	2050-084X
DOI:	10.7554/eLife.100527