A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.

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Title: A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.
Authors: Ferhat L; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Soussi R; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Masse M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Kyriatzis G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Girard S; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Gassiot F; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Gaudin N; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Laurencin M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Bernard A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Bôle A; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Ferracci G; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Smirnova M; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France., Roman F; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France., Dive V; SIMOPRO CEA Saclay, Saclay, France., Cisternino S; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.; Pharmacie, Hôpital Universitaire Necker - Enfants Malades, AP-HP, Paris, France., Temsamani J; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., David M; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Lécorché P; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Jacquot G; VECT-HORUS SAS, Faculté de Médecine, Marseille, France., Khrestchatisky M; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.
Source: ELife [Elife] 2025 Mar 28; Vol. 13. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice.
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  Data: <searchLink fieldCode="AU" term="%22Ferhat+L%22">Ferhat L</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Soussi+R%22">Soussi R</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Masse+M%22">Masse M</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Kyriatzis+G%22">Kyriatzis G</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Girard+S%22">Girard S</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Gassiot+F%22">Gassiot F</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Gaudin+N%22">Gaudin N</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Laurencin+M%22">Laurencin M</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bernard+A%22">Bernard A</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bôle+A%22">Bôle A</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Ferracci+G%22">Ferracci G</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Smirnova+M%22">Smirnova M</searchLink>; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Roman+F%22">Roman F</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Dive+V%22">Dive V</searchLink>; SIMOPRO CEA Saclay, Saclay, France.<br /><searchLink fieldCode="AU" term="%22Cisternino+S%22">Cisternino S</searchLink>; Université Paris Cité, INSERM UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.; Pharmacie, Hôpital Universitaire Necker - Enfants Malades, AP-HP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Temsamani+J%22">Temsamani J</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22David+M%22">David M</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Lécorché+P%22">Lécorché P</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Jacquot+G%22">Jacquot G</searchLink>; VECT-HORUS SAS, Faculté de Médecine, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Khrestchatisky+M%22">Khrestchatisky M</searchLink>; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France.
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