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Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape.

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Title: Preemptive optimization of a clinical antibody for broad neutralization of SARS-CoV-2 variants and robustness against viral escape.
Authors: Zhu F; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Rajan S; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Hayes CF; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Kwong KY; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Goncalves AR; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Zemla AT; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Lau EY; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Zhang Y; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Cai Y; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Goforth JW; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Landajuela M; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Gilchuk P; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Kierny M; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Dippel A; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Amofah B; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Kaplan G; Biologics Engineering, R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Cadevilla Peano V; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Morehouse C; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Sparklin B; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Gopalakrishnan V; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Tuffy KM; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Nguyen A; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Beloor J; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Kijak G; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Liu C; Chinese Academy of Medical Science (CAMS) Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Dijokaite-Guraliuc A; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Mongkolsapaya J; Chinese Academy of Medical Science (CAMS) Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand., Screaton GR; Chinese Academy of Medical Science (CAMS) Oxford Institute, University of Oxford, Oxford OX3 7BN, UK.; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK., Petersen BK; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Desautels TA; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Bennett D; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Conti S; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Segelke BW; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Arrildt KT; Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Kaul S; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Grzesiak EA; Global Security Computing Applications Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., da Silva FL; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Bates TW; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Earnhart CG; Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, US Department of Defense, Frederick, MD 21703, USA., Hopkins S; Joint Research and Development Inc., Stafford, VA 22556, USA., Sundaram S; Center for Bioengineering, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA., Esser MT; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Francica JR; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA., Faissol DM; Computational Engineering Division, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
Corporate Authors: LLNL Generative Unconstrained Intelligent Drug Engineering (GUIDE) consortium
Source: Science advances [Sci Adv] 2025 Mar 28; Vol. 11 (13), pp. eadu0718. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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