Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade.

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Title: Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade.
Authors: Catena X; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Contreras-Alcalde M; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Juan-Larrea N; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Cerezo-Wallis D; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Yale University School of Medicine, New Haven, CT, USA., Calvo TG; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Mucientes C; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Olmeda D; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale, Madrid, Spain., Suárez J; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Oterino-Sogo S; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Martínez L; Flow Cytometry Core Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Megías D; Advanced Optical Microscopy Unit, Instituto de Salud Carlos III (ISCIII), Majadahonda, Spain., Sancho D; Immunobiology Lab, Centro Nacional de Investigación Cardiovasculares (CNIC), Madrid, Spain., Tejedo C; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Frago S; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Dudziak D; Institute of Immunology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Comprehensive Cancer Center Central Germany Jena/Leipzig, Jena, Germany., Seretis A; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria., Stoitzner P; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria., Soengas MS; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. msoengas@cnio.es.
Source: Nature cancer [Nat Cancer] 2025 Apr; Vol. 6 (4), pp. 682-701. Date of Electronic Publication: 2025 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade.
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  Data: <searchLink fieldCode="AU" term="%22Catena+X%22">Catena X</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Contreras-Alcalde+M%22">Contreras-Alcalde M</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Juan-Larrea+N%22">Juan-Larrea N</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cerezo-Wallis+D%22">Cerezo-Wallis D</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Calvo+TG%22">Calvo TG</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mucientes+C%22">Mucientes C</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Olmeda+D%22">Olmeda D</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Instituto de Investigaciones Biomédicas Sols-Morreale, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Suárez+J%22">Suárez J</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Oterino-Sogo+S%22">Oterino-Sogo S</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez+L%22">Martínez L</searchLink>; Flow Cytometry Core Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Megías+D%22">Megías D</searchLink>; Advanced Optical Microscopy Unit, Instituto de Salud Carlos III (ISCIII), Majadahonda, Spain.<br /><searchLink fieldCode="AU" term="%22Sancho+D%22">Sancho D</searchLink>; Immunobiology Lab, Centro Nacional de Investigación Cardiovasculares (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tejedo+C%22">Tejedo C</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Frago+S%22">Frago S</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dudziak+D%22">Dudziak D</searchLink>; Institute of Immunology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Comprehensive Cancer Center Central Germany Jena/Leipzig, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Seretis+A%22">Seretis A</searchLink>; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Stoitzner+P%22">Stoitzner P</searchLink>; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Soengas+MS%22">Soengas MS</searchLink>; Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. msoengas@cnio.es.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2025 Apr; Vol. 6 (4), pp. 682-701. <i>Date of Electronic Publication: </i>2025 Mar 28.
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