Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.

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Title: Gut metagenomes reveal interactions between dietary restriction, ageing and the microbiome in genetically diverse mice.
Authors: Litichevskiy L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Considine M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gill J; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shandar V; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cox TO; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Descamps HC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wright KM; Calico Life Sciences LLC, South San Francisco, CA, USA., Amses KR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dohnalová L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Liou MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tetlak M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Galindo-Fiallos MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wong AC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lundgren P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kim J; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Uhr GT; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rahman RJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mason S; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Merenstein C; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bushman FD; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Raj A; Calico Life Sciences LLC, South San Francisco, CA, USA., Harding F; Calico Life Sciences LLC, South San Francisco, CA, USA., Chen Z; Calico Life Sciences LLC, South San Francisco, CA, USA., Prateek GV; Calico Life Sciences LLC, South San Francisco, CA, USA., Mullis M; Calico Life Sciences LLC, South San Francisco, CA, USA., Deighan AG; The Jackson Laboratory, Bar Harbor, ME, USA., Robinson L; The Jackson Laboratory, Bar Harbor, ME, USA., Tanes C; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA., Bittinger K; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA.; Division of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA., Chakraborty M; Department of Genetics, Stanford University, Stanford, CA, USA., Bhatt AS; Department of Genetics, Stanford University, Stanford, CA, USA.; Divisions of Hematology and Blood & Marrow Transplantation, Department of Medicine, Stanford University, Stanford, CA, USA., Li H; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Barnett I; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davenport ER; Department of Biology, Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA., Broman KW; Department of Biostatistics & Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Levy M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA.; Arc Institute, Palo Alto, CA, USA., Cohen RL; Calico Life Sciences LLC, South San Francisco, CA, USA., Botstein D; Calico Life Sciences LLC, South San Francisco, CA, USA., Freund A; Calico Life Sciences LLC, South San Francisco, CA, USA., Di Francesco A; Calico Life Sciences LLC, South San Francisco, CA, USA., Churchill GA; The Jackson Laboratory, Bar Harbor, ME, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Thaiss CA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. thaiss@stanford.edu.; Department of Pathology, Stanford University, Stanford, CA, USA. thaiss@stanford.edu.; Arc Institute, Palo Alto, CA, USA. thaiss@stanford.edu.
Source: Nature microbiology [Nat Microbiol] 2025 May; Vol. 10 (5), pp. 1240-1257. Date of Electronic Publication: 2025 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2058-5276
DOI:10.1038/s41564-025-01963-3