Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.

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Title: Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup.
Authors: Harnett NG; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Joshi S; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA., Kumar P; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Russell C; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Dillon DG; Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont MA, USA Harvard Medical School, Boston MA, USA., Baker JT; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, USA., Pizzagalli DA; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California, CA, USA., Kaufman ML; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Nickerson LN; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Applied Neuroimaging Statistics Research Laboratory, McLean Hospital, Belmont, MA, USA., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA., Salminen LE; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA., Frijling JL; De Viersprong mental health specialist in personality disorders, family and behavior, Amsterdam, The Netherlands.; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands., Veltman DJ; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Amsterdam UMC Vrije Universiteit, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands., Koch SBJ; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands., Nawijn L; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical Psychology, Leiden University, Leiden, The Netherlands., van Zuiden M; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; Department of Clinical Psychology, Utrecht University, Utrecht, The Netherlands., Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Ipser J; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Zhu X; Department of Bioengineering, The University of Texas at Arlington, TX, USA.; New York State Psychiatric Institute, New York, NY, USA., Ravid O; New York State Psychiatric Institute, New York, NY, USA., Zilcha-Mano S; University of Haifa, Haifa, Israel., Lazarov A; Tel-Aviv University, Tel Aviv-Yafo, Israel.; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA., Suarez-Jimenez B; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA., Sun D; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA.; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Hussain A; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA., Huggins AA; Department of Psychology, University of Arizona, Tucson, AZ, USA., Jovanovic T; Department of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, USA.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Sierk A; University Medical Centre Charité, Berlin, Germany., Manthey A; University Medical Centre Charité, Berlin, Germany., Walter H; University Medical Centre Charité, Berlin, Germany., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., van der Werff SJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands., Vermeiren RRJM; Department of Child and Adolescent Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Říha P; First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic.; Division of Womens Mental Health, McLean Hospital, Belmont, MA, USA., Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA., Rosso IM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA., Olson EA; Crisis Text Line.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard University, Belmont, MA, USA., Liberzon I; Department of Psychiatry, Texas A&M University, Bryan, TX, USA., Angstadt M; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA., Disner SG; Minneapolis VA Health Care System, Minneapolis, MN, USA.; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA., Sponheim SR; Minneapolis VA Health Care System, Minneapolis, MN, USA., Koopowitz SM; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Hofmann D; Institute of Medical Psychology and Systems Neuroscience, University of Mu nster, Mu nster, Germany., Qi R; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Maron-Katz A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Palo Alto, CA, USA., Kunch A; Department of Neurosciences and Psychiatry, University of Toledo, Toledo, OH, USA., Xie H; Department of Neurosciences and Psychiatry, University of Toledo, Toledo, OH, USA., El-Hage W; Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032, Tours, France., Berg H; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Bruce SE; University of Missouri-St. Louis, Department of Psychological Sciences, Center for Trauma Recovery, St. Louis, MO, USA., McLaughlin KA; Department of Psychology, Harvard University, Cambridge, MA, USA., Peverill M; Department of Psychology, University of Washington, Seattle, WA, USA., Sambrook K; Department of Radiology, University of Washington, Seattle, WA, USA., Ross M; Northwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, IL, USA., Herringa RJ; School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA., Nitschke JB; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA., Davidson RJ; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA, Division of Trauma and Acute Care Surgery., deRoon-Cassini TA; Department of Surgery, Medical College of Wisconsin, WI, USA.; Comprehensive Injury Center, Medical College of Wisconsin, WI, USA., Tomas CW; Division of Epidemiology and Social Sciences, Institute of Health and Equity, Medical College of Wisconsin, WI, USA.; Comprehensive Injury Center, Medical College of Wisconsin, WI, USA., Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee, WI, USA, VISUAL PATHWAY STRUCTURE AND PTSD., Blackford JU; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Olatunji BO; Department of Psychology, Vanderbilt University, TN, USA., Nelson SM; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.; Department of Psychiatry and Behavioral Science, Texas A&M University Health Science Center, Bryan, TX, USA., Gordon EM; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Densmore M; Department of Psychiatry, Western University, London, ON, Canada., Théberge J; Department of Psychiatry, Western University, London, ON, Canada., Neufeld RWJ; Department of Psychiatry, Western University, London, ON, Canada., Olff M; Amsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.; ARQ National Psychotrauma Centre, Diemen, The Netherlands., Wang L; State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China., Stein DJ; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Neria Y; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Mueller SC; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium., Daniels JK; Department of Clinical Psychology, University of Groningen, Groningen, The Netherlands.; GGZ Drenthe Mental Health Institute, Department Trauma Center,., Rektor I; CEITEC-Central European Institute of Technology, Multimodal and Functional Neuroimaging Research Group, Masaryk University, Brno, Czech Republic., King A; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Davenport ND; Minneapolis VA Health Care System, Minneapolis, MN, USA., Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Mu nster, Mu nster, Germany., Lu G; Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China., Etkin A; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Palo Alto, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Wang X; Department of Neurosciences and Psychiatry, University of Toledo, Toledo, OH, USA., Quidé Y; School of Psychology, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia., Lissek S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Cisler J; Department of Psychiatry, University of Texas at Austin, Austin, TX, USA., Grupe DW; Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA., Larson C; Department of Psychology, University of Wisconsin- Milwaukee, Milwaukee, WI, USA., Feola B; Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., May G; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.; Veterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA., Abdallah CG; Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Lanius R; Department of Neuroscience, Western University, London, ON, Canada.; Department of Psychiatry, Western University, London, ON, Canada., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA., Morey RA; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA., Ressler K; Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Mar 19. Date of Electronic Publication: 2025 Mar 19.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.03.18.25324188