Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target.

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Title: Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target.
Authors: Wada Y; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Blair MA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Strickland TL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Laudeman JA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Kim K; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Harvey ML; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Solus JF; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Fountain DF; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Shoemaker MB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Kannankeril PJ; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Mar 21. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.03.20.25324224