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Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target.

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Title: Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target.
Authors: Wada Y; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Blair MA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Strickland TL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Laudeman JA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Kim K; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Harvey ML; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Solus JF; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Fountain DF; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Shoemaker MB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN., Kannankeril PJ; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Mar 21. Date of Electronic Publication: 2025 Mar 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target.
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  Data: <searchLink fieldCode="AU" term="%22Wada+Y%22">Wada Y</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Blair+MA%22">Blair MA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Strickland+TL%22">Strickland TL</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Laudeman+JA%22">Laudeman JA</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Harvey+ML%22">Harvey ML</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Solus+JF%22">Solus JF</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Fountain+DF%22">Fountain DF</searchLink>; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Knollmann+BC%22">Knollmann BC</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Shoemaker+MB%22">Shoemaker MB</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Kannankeril+PJ%22">Kannankeril PJ</searchLink>; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Center for Arrhythmia Research and Therapeutic, Vanderbilt University Medical Center, Nashville, TN.; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Mar 21. <i>Date of Electronic Publication: </i>2025 Mar 21.
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        Value: 10.1101/2025.03.20.25324224
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        Text: English
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              Text: 2025 Mar 21
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