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Advancing clinical response against glioblastoma: Evaluating SHP1705 CRY2 activator efficacy in preclinical models and safety in phase I trials.

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Title: Advancing clinical response against glioblastoma: Evaluating SHP1705 CRY2 activator efficacy in preclinical models and safety in phase I trials.
Authors: Chan P; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Nagai Y; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan., Wu Q; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hovsepyan A; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA., Mkhitaryan S; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA., Wang J; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Karapetyan G; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA., Kamenecka T; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA., Solt LA; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA., Cope J; Synchronicity Pharma, San Jose, California, USA., Moats RA; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA., Hirota T; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan., Rich JN; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kay SA; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Source: Neuro-oncology [Neuro Oncol] 2025 Sep 08; Vol. 27 (7), pp. 1772-1786.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chan+P%22">Chan P</searchLink>; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Nagai+Y%22">Nagai Y</searchLink>; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hovsepyan+A%22">Hovsepyan A</searchLink>; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Mkhitaryan+S%22">Mkhitaryan S</searchLink>; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Karapetyan+G%22">Karapetyan G</searchLink>; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kamenecka+T%22">Kamenecka T</searchLink>; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Solt+LA%22">Solt LA</searchLink>; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Cope+J%22">Cope J</searchLink>; Synchronicity Pharma, San Jose, California, USA.<br /><searchLink fieldCode="AU" term="%22Moats+RA%22">Moats RA</searchLink>; Small Animal Imaging Core, Department of Radiology, Children's Hospital Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Hirota+T%22">Hirota T</searchLink>; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Rich+JN%22">Rich JN</searchLink>; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Kay+SA%22">Kay SA</searchLink>; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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  Data: <searchLink fieldCode="JN" term="%22100887420%22">Neuro-oncology</searchLink> [Neuro Oncol] 2025 Sep 08; Vol. 27 (7), pp. 1772-1786.
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              Text: 2025 Sep 08
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