Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells.

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Title: Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells.
Authors: Chen L; Faculty of Pharmaceutical Sciences, UCSI University, 56000, Kuala Lumpur, Malaysia.; Department of Pharmacology, College of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, China., Jiang XD; Department of Pharmacology, College of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, China., Liu XP; Department of Pharmacology, College of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, China., Lee YZ; School of Healthy Aging, Aesthetic and Regenerative Medicine, Faculty of Medicine and Health Sciences, UCSI University, 56000, Kuala Lumpur, Malaysia., Tham CL; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.; Natural Medicine and Product Research Laboratory (NaturMeds), Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia., Yusof R; Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia., Gao S; Department of Pharmacology, College of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, China. gaosi@gxust.edu.cn., Lee MT; Faculty of Pharmaceutical Sciences, UCSI University, 56000, Kuala Lumpur, Malaysia. leemt@ucsiuniversity.edu.my.; UCSI Wellbeing Research Centre, UCSI University, 56000, Kuala Lumpur, Malaysia. leemt@ucsiuniversity.edu.my.
Source: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Apr 01; Vol. 42 (5), pp. 146. Date of Electronic Publication: 2025 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1559-131X
DOI:10.1007/s12032-025-02696-3