FOLFIRI with cetuximab or bevacizumab in RAS wild-type metastatic colorectal cancer: Refining first-line treatment selection by combining clinical parameters: A post hoc analysis of the randomized open-label phase III trial FIRE-3/AIO KRK0306.

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Title: FOLFIRI with cetuximab or bevacizumab in RAS wild-type metastatic colorectal cancer: Refining first-line treatment selection by combining clinical parameters: A post hoc analysis of the randomized open-label phase III trial FIRE-3/AIO KRK0306.
Authors: Holch JW; Department of Medicine III, University Hospital, LMU Munich, Germany; Comprehensive Cancer Center Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Centre (DKFZ), Heidelberg, Germany. Electronic address: julian.holch@med.uni-muenchen.de., Ohnmacht AJ; Computational Health Center, Helmholtz Munich, Neuherberg, Germany; Department of Biology, LMU Munich, Germany., Stintzing S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology, and Cancer Immunology (CCM), Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Centre (DKFZ), Heidelberg, Germany., Heinrich K; Department of Medicine III, University Hospital, LMU Munich, Germany; Comprehensive Cancer Center Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Centre (DKFZ), Heidelberg, Germany., Weiss L; Department of Medicine III, University Hospital, LMU Munich, Germany; Comprehensive Cancer Center Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Centre (DKFZ), Heidelberg, Germany., Probst V; Department of Medicine III, University Hospital, LMU Munich, Germany; Comprehensive Cancer Center Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Centre (DKFZ), Heidelberg, Germany., Stahler A; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology, and Cancer Immunology (CCM), Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Centre (DKFZ), Heidelberg, Germany., Fischer von Weikersthal L; Gesundheitszentrum St Marien, Amberg, Germany., Decker T; Onkologie Ravensburg, Germany., Kiani A; Klinikum Bayreuth GmbH, Bayreuth, Germany and CCC Erlangen-EMN, Germany., Kaiser F; Praxis Hämatologie/Onkologie/Palliativmedizin-Tagesklinik, Landshut, Germany und VK&K Studien GbR, Landshut, Germany., Heintges T; Department of Medicine II, Städtische Kliniken Neuss, Germany., Kahl C; Städtisches Klinikum Magdeburg, Hämatologie/ Onkologie, Magdeburg, Germany; Department of Hematology, Oncology, and Palliative Care, University of Rostock, Rostock, Germany., Kullmann F; Klinikum Weiden, Medizinische Klinik I, Weiden, Germany., Link H; Department of Medicine I, Westpfalz-Klinikum GmbH, Kaiserslautern, Germany., Höffkes HG; Klinikum Fulda, Tumorklinik, Fulda, Germany., Moehler M; Medical Department 1, Johannes-Gutenberg Universität Mainz, Germany., Modest DP; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology, and Cancer Immunology (CCM), Berlin, Germany., Menden MP; Computational Health Center, Helmholtz Munich, Neuherberg, Germany; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia., Heinemann V; Department of Medicine III, University Hospital, LMU Munich, Germany; Comprehensive Cancer Center Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 May 02; Vol. 220, pp. 115388. Date of Electronic Publication: 2025 Mar 25.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0852
DOI:10.1016/j.ejca.2025.115388