The effect of M-current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine.

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Title: The effect of M-current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine.
Authors: Thomson LDJ; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia., Landry SA; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.; School of Psychological Science, Monash University, Melbourne, VIC, Australia., Arellano A; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia., Collet J; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia., Huddle S; Department of Respiratory and Sleep Medicine, Eastern Health, Melbourne, Australia., O'Driscoll DM; Department of Respiratory and Sleep Medicine, Eastern Health, Melbourne, Australia.; Eastern Health Clinical School, Monash University, Melbourne, VIC, Australia., Mann DL; School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, QLD, Australia., Beatty C; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia., Joosten SA; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.; Monash Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, VIC, Australia., Hamilton GS; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.; Monash Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, VIC, Australia., Berger PJ; Hudson Institute of Medical Research, Clayton, VIC, Australia., Cooke I; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia., Edwards BA; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.; School of Psychological Science, Monash University, Melbourne, VIC, Australia.
Source: The Journal of physiology [J Physiol] 2025 May; Vol. 603 (10), pp. 3245-3260. Date of Electronic Publication: 2025 Apr 03.
Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The effect of M-current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine.
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  Data: <searchLink fieldCode="AU" term="%22Thomson+LDJ%22">Thomson LDJ</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Landry+SA%22">Landry SA</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.; School of Psychological Science, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Arellano+A%22">Arellano A</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Collet+J%22">Collet J</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Huddle+S%22">Huddle S</searchLink>; Department of Respiratory and Sleep Medicine, Eastern Health, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22O'Driscoll+DM%22">O'Driscoll DM</searchLink>; Department of Respiratory and Sleep Medicine, Eastern Health, Melbourne, Australia.; Eastern Health Clinical School, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Mann+DL%22">Mann DL</searchLink>; School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Beatty+C%22">Beatty C</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Joosten+SA%22">Joosten SA</searchLink>; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.; Monash Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Hamilton+GS%22">Hamilton GS</searchLink>; School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.; Monash Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Berger+PJ%22">Berger PJ</searchLink>; Hudson Institute of Medical Research, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Cooke+I%22">Cooke I</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Edwards+BA%22">Edwards BA</searchLink>; Department of Physiology, School of Biomedical Sciences and Biomedical Discovery Institute, Monash University, Melbourne, VIC, Australia.; School of Psychological Science, Monash University, Melbourne, VIC, Australia.
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  Data: <searchLink fieldCode="JN" term="%220266262%22">The Journal of physiology</searchLink> [J Physiol] 2025 May; Vol. 603 (10), pp. 3245-3260. <i>Date of Electronic Publication: </i>2025 Apr 03.
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