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High Melphalan Exposure Increases the Risk of Graft-Versus-Host Disease in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.

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Title: High Melphalan Exposure Increases the Risk of Graft-Versus-Host Disease in Pediatric Patients Undergoing Alpha-Beta T-Cell Depleted Haploidentical Transplantation.
Authors: Dvorak CC; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California. Electronic address: Christopher.dvorak@ucsf.edu., Cho S; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at The University of Utah, Salt Lake City, Utah., Salinas Cisneros G; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Higham CS; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Chu J; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Winestone LE; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Temple WC; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Kharbanda S; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Shimano KA; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Avagyan S; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Pauerstein PT; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Division of Pediatric Oncology, University of California San Francisco, San Francisco, California., Huang JN; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Division of Pediatric Hematology, University of California San Francisco, San Francisco, California., Cheng G; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California., Lalefar N; Division of Pediatric Hematology, University of California San Francisco, San Francisco, California., Aguayo-Hiraldo P; Division of Pediatric Hematology, Oncology, and Transplantation and Cellular Therapy, University of Southern California, Children's Hospital Los Angeles, Los Angeles, California., Keizer RJ; Insight RX, San Francisco, California., Pulsipher MA; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at The University of Utah, Salt Lake City, Utah., Long-Boyle JR; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California.
Source: Transplantation and cellular therapy [Transplant Cell Ther] 2025 Jun; Vol. 31 (6), pp. 384.e1-384.e15. Date of Electronic Publication: 2025 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101774629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6367 (Electronic) Linking ISSN: 26666367 NLM ISO Abbreviation: Transplant Cell Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Dvorak+CC%22">Dvorak CC</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California. Electronic address: Christopher.dvorak@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Cho+S%22">Cho S</searchLink>; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at The University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Salinas+Cisneros+G%22">Salinas Cisneros G</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Higham+CS%22">Higham CS</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Chu+J%22">Chu J</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Winestone+LE%22">Winestone LE</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Temple+WC%22">Temple WC</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Kharbanda+S%22">Kharbanda S</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Shimano+KA%22">Shimano KA</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Avagyan+S%22">Avagyan S</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Pauerstein+PT%22">Pauerstein PT</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Division of Pediatric Oncology, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Huang+JN%22">Huang JN</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Division of Pediatric Hematology, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Cheng+G%22">Cheng G</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Lalefar+N%22">Lalefar N</searchLink>; Division of Pediatric Hematology, University of California San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Aguayo-Hiraldo+P%22">Aguayo-Hiraldo P</searchLink>; Division of Pediatric Hematology, Oncology, and Transplantation and Cellular Therapy, University of Southern California, Children's Hospital Los Angeles, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Keizer+RJ%22">Keizer RJ</searchLink>; Insight RX, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Pulsipher+MA%22">Pulsipher MA</searchLink>; Division of Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at The University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Long-Boyle+JR%22">Long-Boyle JR</searchLink>; Division of Pediatric Allergy, Immunology, and Bone Marrow Transplantation, University of California San Francisco, San Francisco, California; Department of Clinical Pharmacy, University of California San Francisco, San Francisco, California.
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