Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.

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Title: Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice.
Authors: Lin J; Department of Pathology, UCSD, La Jolla, California, USA., Callender JA; Department of Pathology, UCSD, La Jolla, California, USA., Mayfield JE; Department of Pathology, UCSD, La Jolla, California, USA., McClatchy DB; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Ojeda-Juárez D; Department of Pathology, UCSD, La Jolla, California, USA., Pourhamzeh M; Department of Pathology, UCSD, La Jolla, California, USA., Soldau K; Department of Pathology, UCSD, La Jolla, California, USA., Kurt TD; Department of Pathology, UCSD, La Jolla, California, USA., Danque GA; Department of Pathology, UCSD, La Jolla, California, USA., Khuu H; Department of Pathology, UCSD, La Jolla, California, USA., Ronson JE; Department of Pathology, UCSD, La Jolla, California, USA., Pizzo DP; Department of Pathology, UCSD, La Jolla, California, USA., Du Y; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Gruber MA; Department of Pathology, UCSD, La Jolla, California, USA., Sevillano AM; Department of Pathology, UCSD, La Jolla, California, USA., Wang J; Department of Pathology, UCSD, La Jolla, California, USA., Orrú CD; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA., Chen J; Department of Pathology, UCSD, La Jolla, California, USA., Funk G; Department of Pathology, UCSD, La Jolla, California, USA., Aguilar-Calvo P; Department of Pathology, UCSD, La Jolla, California, USA., Aulston BD; Department of Pathology, UCSD, La Jolla, California, USA., Roy S; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Rho JM; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Bui JD; Department of Pathology, UCSD, La Jolla, California, USA., Newton AC; Department of Pharmacology, UCSD, La Jolla, California, USA., Lipton SA; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA.; Neurodegeneration New Medicines Center and Department of Molecular & Cellular Biology, The Scripps Research Institute, La Jolla, California, USA., Caughey B; Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Hamilton, Montana, USA., Patrick GN; Department of Biology, and., Doré K; Department of Neurosciences, UCSD, School of Medicine, La Jolla, California, USA., Yates JR 3rd; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA., Sigurdson CJ; Department of Pathology, UCSD, La Jolla, California, USA.; Department of Medicine, UCSD, La Jolla, California, USA.; Department of Pathology, Microbiology, and Immunology, UCD, Davis, California, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2025 Apr 04; Vol. 135 (10). Date of Electronic Publication: 2025 Apr 04 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1558-8238
DOI:10.1172/JCI186432